Paulina Chinchilla-López1, Oscar Ramírez-Pérez1, Vania Cruz-Ramón1, Samuel Canizales-Quinteros2, Aarón Domínguez-López3, Guadalupe Ponciano-Rodríguez4, Fausto Sánchez-Muñoz5, Nahum Méndez-Sánchez1. 1. Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City. 2. Unit of Genomic, National Institute of Genomic, Mexico City, Mexico. 3. Department of Postgraduate Courses and Research, Laboratory of Molecular Biology, Superior School of Medicine, National Polytechnic Institute. Mexico City, Mexico. 4. Public Health Department, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico. 5. Department of Immunology, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.
Abstract
BACKGROUND: The gene for patatin-like phospholipase domain containing 3 (PNPLA3) is associated with nonalcoholic fatty liver disease (NAFLD) development. We previously found that Mexican indigenous population had the highest frequency reported of the PNPLA3 148M risk allele. Further, we observed a relationship between M148M genotype with elevated ALT levels in individuals with normal weight, overweight and obese. We sought to investigate whether PNPLA3 polymorphism is associated with NAFLD development in Mexicans. MATERIAL AND METHODS: We enrolled 189 Mexican patients with NAFLD and 201 healthy controls. Anthropometric, metabolic, and biochemical variables were measured, and rs738409 (Ile148Met substitution) polymorphism was genotyped by sequencing. RESULTS: Logistic regression analysis, using a recessive model, suggested that PNPLA3 polymorphism in Mexican population is significantly associated (OR = 1.711, 95% CI: 1.014-2.886; P = 0.044) with NAFLD. CONCLUSIONS: The PNPLA3 gene is associated with NAFLD in Mexican population. More studies are required to explain the high prevalence of PNPLA3 polymorphism in Mexican-Americans, Mexican-Indians, and Mexican-Mestizos.
BACKGROUND: The gene for patatin-like phospholipase domain containing 3 (PNPLA3) is associated with nonalcoholic fatty liver disease (NAFLD) development. We previously found that Mexican indigenous population had the highest frequency reported of the PNPLA3 148M risk allele. Further, we observed a relationship between M148M genotype with elevated ALT levels in individuals with normal weight, overweight and obese. We sought to investigate whether PNPLA3 polymorphism is associated with NAFLD development in Mexicans. MATERIAL AND METHODS: We enrolled 189 Mexican patients with NAFLD and 201 healthy controls. Anthropometric, metabolic, and biochemical variables were measured, and rs738409 (Ile148Met substitution) polymorphism was genotyped by sequencing. RESULTS: Logistic regression analysis, using a recessive model, suggested that PNPLA3 polymorphism in Mexican population is significantly associated (OR = 1.711, 95% CI: 1.014-2.886; P = 0.044) with NAFLD. CONCLUSIONS: The PNPLA3 gene is associated with NAFLD in Mexican population. More studies are required to explain the high prevalence of PNPLA3 polymorphism in Mexican-Americans, Mexican-Indians, and Mexican-Mestizos.
Authors: Nahum Méndez-Sánchez; Eira Cerda-Reyes; Fátima Higuera-de-la-Tijera; Ana K Salas-García; Samantha Cabrera-Palma; Guillermo Cabrera-Álvarez; Carlos Cortez-Hernández; Luis A Pérez-Arredondo; Emma Purón-González; Edgar Coronado-Alejandro; Arturo Panduro; Heriberto Rodríguez-Hernández; Vania C Cruz-Ramón; Alejandro Valencia-Rodríguez; Xingshun Qi; Nashla Hamdan-Pérez; Nancy E Aguilar-Olivos; Beatriz Barranco-Fragoso; Oscar Ramírez-Pérez; Alfonso Vera-Barajas Journal: F1000Res Date: 2020-01-28
Authors: Sana Mansoor; Anshu Maheshwari; Matthew Di Guglielmo; Katryn Furuya; Makala Wang; Erin Crowgey; Zarela Molle-Rios; Zhaoping He Journal: Pediatr Gastroenterol Hepatol Nutr Date: 2021-09-08
Authors: Ana Luisa Ordoñez-Vázquez; Eva Juárez-Hernández; Julia María Zuarth-Vázquez; Martha Helena Ramos-Ostos; Misael Uribe; Graciela Castro-Narro; Iván López-Méndez Journal: Int J Environ Res Public Health Date: 2022-09-27 Impact factor: 4.614