Literature DB >> 29468901

Osteochondritis Dissecans of the Knee - Conservative Treatment Strategies: A Systematic Review.

Luca Andriolo1, Christian Candrian2, Tiziana Papio1, Alessia Cavicchioli1, Francesco Perdisa1, Giuseppe Filardo1.   

Abstract

OBJECTIVE: Osteochondritis dissecans (OCD) lesions are a relevant problem that affects the long-term prognosis of young patients. The purpose of this study was to analyze the evidence on potential and indications of nonsurgical treatment strategies for knee OCD.
DESIGN: The search was conducted on 3 medical electronic databases according to PRISMA guidelines, including reports of any level of evidence dealing with the conservative management of knee OCD. Of 1688 identified records, 55 full-text articles were screened: 27 studies met the inclusion criteria, for a total of 908 knees, and were used for the analysis.
RESULTS: No high-level studies were found: 24 articles were case series and 3 case reports, reporting on different treatments summarized in (1) restriction of physical activity, (2) physiokinesitherapy and muscle-strengthening exercises, (3) physical instrumental therapies, (4) limitation of weightbearing, and (5) immobilization. The analysis showed an overall healing rate of 61.4%, with large variability (10.4%-95.8%). A conservative treatment based on restriction of sport and strenuous activities seems a favorable approach, possibly combined with physiokinesitherapy. Negative prognostic factors were also identified: larger lesion size, more severe lesion stages, older age and skeletal maturity, discoid meniscus, and clinical presentation with swelling or locking.
CONCLUSIONS: The literature on conservative treatments for knee OCD is scarce. Among different non-surgical treatment options, strenuous activity restriction seems a favorable approach, whereas there is no evidence that physical instrumental therapy, immobilization, or weightbearing limitation could be beneficial. However, further studies are needed to improve treatment potential and indications for the conservative management of knee OCD.

Entities:  

Keywords:  cartilage; conservative treatment; knee; osteochondral; osteochondritis dissecans

Mesh:

Year:  2018        PMID: 29468901      PMCID: PMC6585290          DOI: 10.1177/1947603518758435

Source DB:  PubMed          Journal:  Cartilage        ISSN: 1947-6035            Impact factor:   4.634


  35 in total

1.  Arthroscopic versus conservative treatment of osteochondritis dissecans of the knee: value of magnetic resonance imaging in therapy planning and follow-up.

Authors:  Ingke Jürgensen; Georg Bachmann; Iris Schleicher; Holger Haas
Journal:  Arthroscopy       Date:  2002-04       Impact factor: 4.772

Review 2.  Management of osteochondritis dissecans of the knee: current concepts review.

Authors:  Mininder S Kocher; Rachael Tucker; Theodore J Ganley; John M Flynn
Journal:  Am J Sports Med       Date:  2006-07       Impact factor: 6.202

3.  Osteochondritis dissecans of the knee. A clinical survey.

Authors:  P Aichroth
Journal:  J Bone Joint Surg Br       Date:  1971-08

4.  Analysis of risk factors for poor prognosis in conservatively managed juvenile osteochondritis dissecans of the lateral femoral condyle.

Authors:  Hiroshi Nakayama; Tomoya Iseki; Syunichiro Kambara; Shinichi Yoshiya
Journal:  Knee       Date:  2016-11-07       Impact factor: 2.199

5.  Natural progression of osteo-chondral defect in the femoral condyle.

Authors:  Divya Prakash; Duncan Learmonth
Journal:  Knee       Date:  2002-02       Impact factor: 2.199

6.  Osteochondritis dissecans: a multicenter study of the European Pediatric Orthopedic Society.

Authors:  F Hefti; J Beguiristain; R Krauspe; B Möller-Madsen; V Riccio; C Tschauner; R Wetzel; R Zeller
Journal:  J Pediatr Orthop B       Date:  1999-10       Impact factor: 1.041

7.  Osteochondritis of the femoral condyles in children and adolescents: our experience over the last 28 years.

Authors:  Santiago Cepero; Rosendo Ullot; Sergi Sastre
Journal:  J Pediatr Orthop B       Date:  2005-01       Impact factor: 1.041

8.  The healing potential of stable juvenile osteochondritis dissecans knee lesions.

Authors:  Eric J Wall; Jason Vourazeris; Gregory D Myer; Kathleen H Emery; Jon G Divine; Todd G Nick; Timothy E Hewett
Journal:  J Bone Joint Surg Am       Date:  2008-12       Impact factor: 5.284

9.  Nonoperative Management of Osteochondritis Dissecans of the Knee: Progression to Osteoarthritis and Arthroplasty at Mean 13-Year Follow-up.

Authors:  Thomas L Sanders; Ayoosh Pareek; Nick R Johnson; James L Carey; Travis G Maak; Michael J Stuart; Aaron J Krych
Journal:  Orthop J Sports Med       Date:  2017-07-24

10.  Extracorporeal shock waves down-regulate the expression of interleukin-10 and tumor necrosis factor-alpha in osteoarthritic chondrocytes.

Authors:  Biagio Moretti; Florenzo Iannone; Angela Notarnicola; Giovanni Lapadula; Lorenzo Moretti; Vittorio Patella; Raffaele Garofalo
Journal:  BMC Musculoskelet Disord       Date:  2008-01-31       Impact factor: 2.362

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  13 in total

Review 1.  Surgical Management of Osteochondral Defects of the Knee: An Educational Review.

Authors:  Matthew Howell; Quintin Liao; Christopher W Gee
Journal:  Curr Rev Musculoskelet Med       Date:  2021-02-15

Review 2.  Treatment of unstable knee osteochondritis dissecans in the young adult: results and limitations of surgical strategies-The advantages of allografts to address an osteochondral challenge.

Authors:  Giuseppe Filardo; Luca Andriolo; Francesc Soler; Massimo Berruto; Paolo Ferrua; Peter Verdonk; Frederic Rongieras; Dennis C Crawford
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2018-12-06       Impact factor: 4.342

3.  Knee osteochondritis dissecans-treatment technical aspects.

Authors:  Mats Brittberg
Journal:  J Orthop       Date:  2022-08-11

4.  Treatment of Juvenile Knee Osteochondritis Dissecans with a Cell-Free Biomimetic Osteochondral Scaffold: Clinical and MRI Results at Mid-Term Follow-up.

Authors:  Andrea Sessa; Iacopo Romandini; Luca Andriolo; Alessandro Di Martino; Maurizio Busacca; Stefano Zaffagnini; Giuseppe Filardo
Journal:  Cartilage       Date:  2020-09-10       Impact factor: 3.117

5.  Longitudinal 3T MRI T2 * mapping of Juvenile osteochondritis dissecans (JOCD) lesions differentiates operative from non-operative patients-Pilot study.

Authors:  Abdul Wahed Kajabi; Štefan Zbýň; Casey P Johnson; Marc A Tompkins; Bradley J Nelson; Takashi Takahashi; Kevin G Shea; Shelly Marette; Cathy S Carlson; Jutta M Ellermann
Journal:  J Orthop Res       Date:  2022-04-17       Impact factor: 3.102

6.  Matrix-assisted chondrocyte transplantation with bone grafting for knee osteochondritis dissecans: stable results at 12 years.

Authors:  Luca Andriolo; Alessandro Di Martino; Sante Alessandro Altamura; Angelo Boffa; Alberto Poggi; Maurizio Busacca; Stefano Zaffagnini; Giuseppe Filardo
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2020-08-18       Impact factor: 4.342

7.  Osteochondritis Dissecans of the Knee: Etiology and Pathogenetic Mechanisms. A Systematic Review.

Authors:  Luca Andriolo; Dennis C Crawford; Davide Reale; Stefano Zaffagnini; Christian Candrian; Alessia Cavicchioli; Giuseppe Filardo
Journal:  Cartilage       Date:  2018-07-12       Impact factor: 4.634

8.  Inhibitory effect of red LED irradiation on fibroblasts and co-culture of adipose-derived mesenchymal stem cells.

Authors:  Viviane Theodoro; Lucas de Oliveira Fujii; Leticia Dudri Lucke; Fernanda Oriani Bortolazzo; Daniela Fernanda Dezotti Silva; Giane Daniela Carneiro; Maria Esméria Corezola do Amaral; Camila Andréa de Oliveira; Thiago Antonio Moretti de Andrade; André Luis Bombeiro; Cristina Pontes Vicente; Fernando Russo Costa do Bomfim; Alexandre Leite Rodrigues de Oliveira; Vanderlei Salvador Bagnato; Marcelo Augusto Marretto Esquisatto; Fernanda Aparecida Sampaio Mendonça; Gláucia Maria Tech Dos Santos; Andrea Aparecida de Aro
Journal:  Heliyon       Date:  2020-05-12

9.  Osteochondral autograft transplantation versus autologous bone-cartilage paste grafting for the treatment of knee osteochondritis dissecans.

Authors:  Alessandro Di Martino; Simone Silva; Luca Andriolo; Giulia Merli; Davide Reale; Stefano Zaffagnini; Giuseppe Filardo
Journal:  Int Orthop       Date:  2020-09-21       Impact factor: 3.075

10.  Adjunct use of radiofrequency coblation for osteochondritis dissecans in children: A case report.

Authors:  Reed Estes
Journal:  Medicine (Baltimore)       Date:  2020-08-28       Impact factor: 1.817

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