Literature DB >> 29467865

Discoidin domain receptor 1: New star in cancer-targeted therapy and its complex role in breast carcinoma.

Hui Jing1, Jingyuan Song1,2, Junnian Zheng1,2,3.   

Abstract

Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagens that performs a critical role in cell attachment, migration, survival and proliferation. The functions of DDR1 in various types of tumor have been studied extensively. However, in breast carcinoma, the roles of collagen-evoked DDR1 remain ill defined. Although a number of studies have reported that DDR1 promotes apoptosis and inhibits migration in breast carcinoma, it has also been reported to be associated with tumor cell survival, chemoresistance to genotoxic drugs and the facilitation of invasion. The present review summarizes current progress and the complex effects of DDR1 in the field of breast carcinoma, and presents DDR1 as a promising therapeutic target.

Entities:  

Keywords:  breast carcinoma; collagen; discoidin domain receptor 1; epithelial-mesenchymal transition; migration

Year:  2018        PMID： 29467865      PMCID： PMC5795932          DOI： 10.3892/ol.2018.7795

Source DB:  PubMed          Journal:  Oncol Lett        ISSN： 1792-1074            Impact factor:   2.967


  87 in total

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4.  Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2.

Authors:  Rosalyn Ram; Gustavo Lorente; Karoly Nikolich; Roman Urfer; Erik Foehr; Usha Nagavarapu
Journal:  J Neurooncol       Date:  2006-02       Impact factor: 4.130

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Authors:  Birgit Leitinger
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6.  Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion.

Authors:  Qingli Shen; Vito R Cicinnati; Xiaoyong Zhang; Speranta Iacob; Frank Weber; Georgios C Sotiropoulos; Arnold Radtke; Mengji Lu; Andreas Paul; Guido Gerken; Susanne Beckebaum
Journal:  Mol Cancer       Date:  2010-08-27       Impact factor: 27.401

7.  Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.

Authors:  James S Duncan; Martin C Whittle; Kazuhiro Nakamura; Amy N Abell; Alicia A Midland; Jon S Zawistowski; Nancy L Johnson; Deborah A Granger; Nicole Vincent Jordan; David B Darr; Jerry Usary; Pei-Fen Kuan; David M Smalley; Ben Major; Xiaping He; Katherine A Hoadley; Bing Zhou; Norman E Sharpless; Charles M Perou; William Y Kim; Shawn M Gomez; Xin Chen; Jian Jin; Stephen V Frye; H Shelton Earp; Lee M Graves; Gary L Johnson
Journal:  Cell       Date:  2012-04-13       Impact factor: 41.582

8.  Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1.

Authors:  Huifang Xu; Nicolas Raynal; Stavros Stathopoulos; Johanna Myllyharju; Richard W Farndale; Birgit Leitinger
Journal:  Matrix Biol       Date:  2010-10-28       Impact factor: 11.583

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Journal:  Breast Cancer Res       Date:  2016-02-17       Impact factor: 6.466
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  13 in total

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Journal:  Front Pharmacol       Date:  2018-08-03       Impact factor: 5.810

4.  Targeting Discoidin Domain Receptor 1 (DDR1) Signaling and Its Crosstalk with β1-integrin Emerges as a Key Factor for Breast Cancer Chemosensitization upon Collagen Type 1 Binding.

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5.  Novel secretome-to-transcriptome integrated or secreto-transcriptomic approach to reveal liquid biopsy biomarkers for predicting individualized prognosis of breast cancer patients.

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6.  Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma.

Authors:  Yiran Tao; Ruixue Wang; Qinhuai Lai; Mengdan Wu; Yuxi Wang; Xiaohua Jiang; Lishi Zeng; Shijie Zhou; Zhongping Li; Tinghan Yang; Yuqin Yao; Yangping Wu; Lin Yu; Yuyin Fu; Weirong Lai; Yujia Peng; Ying Lu; Zhixiong Zhang; Cuiyu Guo; Guangbing Zhang; Lantu Gou; Jinliang Yang
Journal:  Mol Oncol       Date:  2019-07-22       Impact factor: 6.603

7.  Overexpression of DDR1 Promotes Migration, Invasion, Though EMT-Related Molecule Expression and COL4A1/DDR1/MMP-2 Signaling Axis.

Authors:  Xin Xie; Hongchao He; Ning Zhang; Xiaojing Wang; Wenbin Rui; Danfeng Xu; Yu Zhu
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Review 9.  Discoidin Domain Receptor 1, a Potential Biomarker and Therapeutic Target in Hepatocellular Carcinoma.

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10.  CSF MicroRNAs Reveal Impairment of Angiogenesis and Autophagy in Parkinson Disease.

Authors:  Alan J Fowler; Jaeil Ahn; Michaeline Hebron; Timothy Chiu; Reem Ayoub; Sanjana Mulki; Habtom Ressom; Yasar Torres-Yaghi; Barbara Wilmarth; Fernando L Pagan; Charbel Moussa
Journal:  Neurol Genet       Date:  2021-11-12
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