| Literature DB >> 29466777 |
Yu Li1, Qiuyan Shi1, Jiajia Shao2, Yaping Yuan3, Zhigang Yang1, Shizhen Chen3, Xin Zhou3, Shijun Wen2, Zhong-Xing Jiang4.
Abstract
To improve the druggability of salinomycin, a 20-epi-amino-20-deoxysalinomycin derivatives library was synthesized with high efficacy from which a few salinomycin derivatives with high potency and selectivity were identified through comprehensive cytotoxicity assay, including a fluorine-19 magnetic resonance sensitive tool molecule. Using a K-ras cellular model, salinomycin and its derivatives showed different molecular mode of action from literature reports. These results would be valuable for developing salinomycin-based cancer therapy.Entities:
Keywords: (19)F MRI; Anti-cancer drugs; K-ras pathway; Nature product modification; Salinomycin; Staudinger reaction
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Year: 2018 PMID： 29466777 DOI： 10.1016/j.ejmech.2018.02.004
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514