Literature DB >> 29465671

Higher Levels of a Cytotoxic Protein, Vaginolysin, in Lactobacillus-Deficient Community State Types at the Vaginal Mucosa.

Rebecca G Nowak, Tara M Randis, Purnahamsi Desai, Xin He, Courtney K Robinson, Jessica M Rath, Elbert D Glover, Adam J Ratner, Jacques Ravel, Rebecca M Brotman.   

Abstract

Vaginolysin (VLY), a cytotoxic protein produced by Gardnerella vaginalis, may contribute to bacterial vaginosis. We observed that women with G. vaginalis, low levels of lactobacilli, history of vaginal douching, higher Nugent scores, and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. Vaginolysin's role in bacterial vaginosis warrants further evaluation.

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Year:  2018        PMID： 29465671      PMCID： PMC5847449          DOI： 10.1097/OLQ.0000000000000774

Source DB:  PubMed          Journal:  Sex Transm Dis        ISSN： 0148-5717            Impact factor:   2.830


  24 in total

1.  Endotoxin and interleukin-1 alpha in the cervical mucus and vaginal fluid of pregnant women with bacterial vaginosis.

Authors:  J J Platz-Christensen; I Mattsby-Baltzer; P Thomsen; N Wiqvist
Journal:  Am J Obstet Gynecol       Date:  1993-11       Impact factor: 8.661

2.  Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation.

Authors:  R P Nugent; M A Krohn; S L Hillier
Journal:  J Clin Microbiol       Date:  1991-02       Impact factor: 5.948

3.  Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis.

Authors:  M Reza Zariffard; Richard M Novak; Nell Lurain; Beverly E Sha; Parrie Graham; Gregory T Spear
Journal:  J Infect Dis       Date:  2005-04-28       Impact factor: 5.226

4.  Among pregnant women with bacterial vaginosis, the hydrolytic enzymes sialidase and prolidase are positively associated with interleukin-1beta.

Authors:  Sabina Cauci; Jennifer Flatow Culhane; Manuela Di Santolo; Kelly McCollum
Journal:  Am J Obstet Gynecol       Date:  2007-08-22       Impact factor: 8.661

5.  Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis.

Authors:  Sujatha Srinivasan; Congzhou Liu; Caroline M Mitchell; Tina L Fiedler; Katherine K Thomas; Kathy J Agnew; Jeanne M Marrazzo; David N Fredricks
Journal:  PLoS One       Date:  2010-04-15       Impact factor: 3.240

6.  Using an in-vitro biofilm model to assess the virulence potential of bacterial vaginosis or non-bacterial vaginosis Gardnerella vaginalis isolates.

Authors:  Joana Castro; Patrícia Alves; Cármen Sousa; Tatiana Cereija; Ângela França; Kimberly K Jefferson; Nuno Cerca
Journal:  Sci Rep       Date:  2015-06-26       Impact factor: 4.379

7.  Antibody-based detection and inhibition of vaginolysin, the Gardnerella vaginalis cytolysin.

Authors:  Tara M Randis; Ritwij Kulkarni; Jorge L Aguilar; Adam J Ratner
Journal:  PLoS One       Date:  2009-04-16       Impact factor: 3.240

8.  Reciprocal interference between Lactobacillus spp. and Gardnerella vaginalis on initial adherence to epithelial cells.

Authors:  Joana Castro; Ana Henriques; António Machado; Mariana Henriques; Kimberly K Jefferson; Nuno Cerca
Journal:  Int J Med Sci       Date:  2013-07-20       Impact factor: 3.738

9.  Influence of vaginal bacteria and D- and L-lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer: implications for protection against upper genital tract infections.

Authors:  Steven S Witkin; Helena Mendes-Soares; Iara M Linhares; Aswathi Jayaram; William J Ledger; Larry J Forney
Journal:  mBio       Date:  2013-08-06       Impact factor: 7.867

10.  Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota.

Authors:  Deirdre E O'Hanlon; Thomas R Moench; Richard A Cone
Journal:  PLoS One       Date:  2013-11-06       Impact factor: 3.240
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  5 in total

1.  Interaction of Gardnerella vaginalis and Vaginolysin with the Apical versus Basolateral Face of a Three-Dimensional Model of Vaginal Epithelium.

Authors:  Erin M Garcia; Vita Kraskauskiene; Jennifer E Koblinski; Kimberly K Jefferson
Journal:  Infect Immun       Date:  2019-03-25       Impact factor: 3.441

Review 2.  Cholesterol-Dependent Cytolysins Produced by Vaginal Bacteria: Certainties and Controversies.

Authors:  Milda Pleckaityte
Journal:  Front Cell Infect Microbiol       Date:  2020-01-10       Impact factor: 5.293

Review 3.  Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health.

Authors:  Wallace Jeng Yang Chee; Shu Yih Chew; Leslie Thian Lung Than
Journal:  Microb Cell Fact       Date:  2020-11-07       Impact factor: 5.328

4.  Sequence Comparison of Vaginolysin from Different Gardnerella Species.

Authors:  Erin M Garcia; Myrna G Serrano; Laahirie Edupuganti; David J Edwards; Gregory A Buck; Kimberly K Jefferson
Journal:  Pathogens       Date:  2021-01-20

5.  The Alterations of Vaginal Microbiome in HPV16 Infection as Identified by Shotgun Metagenomic Sequencing.

Authors:  Qian Yang; Yaping Wang; Xinyi Wei; Jiawei Zhu; Xinyu Wang; Xing Xie; Weiguo Lu
Journal:  Front Cell Infect Microbiol       Date:  2020-06-23       Impact factor: 5.293
  5 in total

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