Literature DB >> 29465344

Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe.

Stephen V Gordon1,2, Tanya Parish3.   

Abstract

Mycobacterium tuberculosis is an expert and deadly pathogen, causing the disease tuberculosis (TB) in humans. It has several notable features: the ability to enter non-replicating states for long periods and cause latent infection; metabolic remodelling during chronic infection; a thick, waxy cell wall; slow growth rate in culture; and intrinsic drug resistance and antibiotic tolerance. As a pathogen, M. tuberculosis has a complex relationship with its host, is able to replicate inside macrophages, and expresses diverse immunomodulatory molecules. M. tuberculosis currently causes over 1.8 million deaths a year, making it the world's most deadly human pathogen.

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Year:  2018        PMID： 29465344     DOI： 10.1099/mic.0.000601

Source DB:  PubMed          Journal:  Microbiology        ISSN： 1350-0872            Impact factor:   2.777


  21 in total

1.  Reduction of Human DNA Contamination in Clinical Cerebrospinal Fluid Specimens Improves the Sensitivity of Metagenomic Next-Generation Sequencing.

Authors:  Xin-Chao Ji; Lin-Fu Zhou; Chao-Yang Li; Ya-Jun Shi; Meng-Li Wu; Yun Zhang; Xiao-Fei Fei; Gang Zhao
Journal:  J Mol Neurosci       Date:  2020-01-31       Impact factor: 3.444

2.  Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.

Authors:  Peter C Ray; Margaret Huggett; Penelope A Turner; Malcolm Taylor; Laura A T Cleghorn; Julie Early; Anuradha Kumar; Shilah A Bonnett; Lindsay Flint; Douglas Joerss; James Johnson; Aaron Korkegian; Steven Mullen; Abraham L Moure; Susan H Davis; Dinakaran Murugesan; Michael Mathieson; Nicola Caldwell; Curtis A Engelhart; Dirk Schnappinger; Ola Epemolu; Fabio Zuccotto; Jennifer Riley; Paul Scullion; Laste Stojanovski; Lisa Massoudi; Gregory T Robertson; Anne J Lenaerts; Gail Freiberg; Dale J Kempf; Thierry Masquelin; Philip A Hipskind; Joshua Odingo; Kevin D Read; Simon R Green; Paul G Wyatt; Tanya Parish
Journal:  ACS Omega       Date:  2021-01-13

3.  The driving force for mycolic acid export by mycobacterial MmpL3 is proton translocation.

Authors:  Tanya Parish
Journal:  Proc Natl Acad Sci U S A       Date:  2022-08-08       Impact factor: 12.779

4.  Evaluation of EZplex MTBC/NTM Real-Time PCR kit: diagnostic accuracy and efficacy in vaccination.

Authors:  Suengmok Lee; Kyung-A Hwang; Ji-Hoon Ahn; Jae-Hwan Nam
Journal:  Clin Exp Vaccine Res       Date:  2018-07-31

5.  Construction of an overexpression library for Mycobacterium tuberculosis.

Authors:  Eduard Melief; Rachel Kokoczka; Megan Files; Mai Ann Bailey; Torey Alling; Hongye Li; James Ahn; Ayesha Misquith; Aaron Korkegian; David Roberts; James Sacchettini; Tanya Parish
Journal:  Biol Methods Protoc       Date:  2018-08-20

6.  Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors.

Authors:  Bryan J Berube; Dara Russell; Lina Castro; Seoung-Ryoung Choi; Prabagaran Narayanasamy; Tanya Parish
Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

7.  Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages.

Authors:  Yaohui Sun; Brian Reid; Fernando Ferreira; Guillaume Luxardi; Li Ma; Kristen L Lokken; Kan Zhu; Gege Xu; Yuxin Sun; Volodymyr Ryzhuk; Betty P Guo; Carlito B Lebrilla; Emanual Maverakis; Alex Mogilner; Min Zhao
Journal:  PLoS Biol       Date:  2019-04-09       Impact factor: 8.029

8.  Effects of Mycobacterium vaccae vaccine in a mouse model of tuberculosis: protective action and differentially expressed genes.

Authors:  Wen-Ping Gong; Yan Liang; Yan-Bo Ling; Jun-Xian Zhang; You-Rong Yang; Lan Wang; Jie Wang; Ying-Chang Shi; Xue-Qiong Wu
Journal:  Mil Med Res       Date:  2020-06-03

9.  Pulmonary coinfection of Mycobacterium tuberculosis and Tropheryma whipplei: a case report.

Authors:  Binghua Zhu; Jing Tang; Rong Fang; Xuejie Fei; Qing Wang; Wenqing Wang; Xueqin Wu; Chao Liu; Qian Wang
Journal:  J Med Case Rep       Date:  2021-07-09

10.  A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis.

Authors:  Julie V Early; Steven Mullen; Tanya Parish
Journal:  PLoS One       Date:  2019-10-07       Impact factor: 3.240
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