Jiong Qin1,2, Yi Wang3, Xin-Fang Huang4, Yu-Qin Zhang5, Fang Fang6, Yin-Bo Chen7, Zhong-Dong Lin8, Yan-Chun Deng9, Fei Yin10, Li Jiang11, Ye Wu12, Xiang-Shu Hu13. 1. Department of Pediatrics, Peking University People's Hospital, No. 11 Xi Zhi Men Nan Da Jie, Xicheng District, Beijing, 100044, China. jiongqinbeijing01@126.com. 2. Department of Pediatrics, Peking University First Hospital, Beijing, China. jiongqinbeijing01@126.com. 3. Department of Neurology, Children's Hospital, Fudan University, Shanghai, China. 4. Department of Pediatrics, Quanzhou Women's and Children's Hospital, Quanzhou, China. 5. Department of Neurology, Tianjin Children's Hospital, Tianjin, China. 6. Department of Neurology, Beijing Children's Hospital, Beijing, China. 7. Department of Pediatric Neurology, The First Bethune Hospital, Jilin University, Changchun, China. 8. Department of Pediatric Neurology, The 2nd Affiliated Hospital, Wenzhou Medical University, Wenzhou, China. 9. Department of Neurology, Xijing Hospital, Xi'an, China. 10. Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China. 11. Department of Neurology, Children's Hospital, Chongqing Medical University, Chongqing, China. 12. Department of Pediatrics, Peking University First Hospital, Beijing, China. 13. The third Department of Neurology, Guangdong 999 Brain Hospital, Guangzhou, China.
Abstract
BACKGROUND: This study aimed to assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-5 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China. METHODS: This 26-week, prospective, single-arm, multicenter, observational study recruited pediatric patients aged 2-5 years with PS or GTCS suitable for OXC oral suspension treatment based on physicians' judgments from 11 medical centers in China. Enrolled subjects started OXC oral suspension treatment as monotherapy or in combination with other antiepileptic drugs. Primary efficacy outcome was the percentage of pediatric subjects achieving ≥ 50% seizure frequency reduction at the end of the 26-week treatment. Secondary efficacy-related parameters and safety parameters such as adverse events (AEs) and serious AEs (SAEs) were also monitored during the 26-week treatment period. RESULTS: Six hundred and six pediatric patients were enrolled and 531 (87.6%) completed the study. After 26 weeks of treatment, 93.3% subjects achieved ≥ 50% seizure frequency reduction, and 81.8% achieved 100% seizure frequency reduction compared to baseline. Among different seizure types, OXC was effective in all subjects with simple PS and in > 90% of subject with other type of seizure present in the study. AEs were observed in 49 (8.1%) subjects. Only three subjects experienced SAE. Rash (n = 18, 2.97%) was the most common AE. Only 17 subjects discontinued due to AEs. CONCLUSION: This study, reporting the real-world data, further confirms the efficacy and good safety profile of OXC oral suspension in Chinese pediatric patients aged 2-5 years with PS and/or GTCS.
BACKGROUND: This study aimed to assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-5 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China. METHODS: This 26-week, prospective, single-arm, multicenter, observational study recruited pediatric patients aged 2-5 years with PS or GTCS suitable for OXC oral suspension treatment based on physicians' judgments from 11 medical centers in China. Enrolled subjects started OXC oral suspension treatment as monotherapy or in combination with other antiepileptic drugs. Primary efficacy outcome was the percentage of pediatric subjects achieving ≥ 50% seizure frequency reduction at the end of the 26-week treatment. Secondary efficacy-related parameters and safety parameters such as adverse events (AEs) and serious AEs (SAEs) were also monitored during the 26-week treatment period. RESULTS: Six hundred and six pediatric patients were enrolled and 531 (87.6%) completed the study. After 26 weeks of treatment, 93.3% subjects achieved ≥ 50% seizure frequency reduction, and 81.8% achieved 100% seizure frequency reduction compared to baseline. Among different seizure types, OXC was effective in all subjects with simple PS and in > 90% of subject with other type of seizure present in the study. AEs were observed in 49 (8.1%) subjects. Only three subjects experienced SAE. Rash (n = 18, 2.97%) was the most common AE. Only 17 subjects discontinued due to AEs. CONCLUSION: This study, reporting the real-world data, further confirms the efficacy and good safety profile of OXC oral suspension in Chinese pediatric patients aged 2-5 years with PS and/or GTCS.
Authors: E D Belousova; K Iu Mukhin; N A Ermolenko; V I Guzeva; M D Tysiachina; M B Mironov; A S Petrukhin Journal: Zh Nevrol Psikhiatr Im S S Korsakova Date: 2010
Authors: E Franzoni; C Garone; J Sarajlija; S Gualandi; E Malaspina; I Cecconi; F C Moscano; V Marchiani Journal: Seizure Date: 2006-03-22 Impact factor: 3.184