M Gröschel1, A Ernst2, D Basta2. 1. Klinik für Hals‑, Nasen‑, Ohrenheilkunde, BG Klinikum Unfallkrankenhaus Berlin gGmbH, Warener Str. 7, 12683, Berlin, Deutschland. moritz.groeschel@biologie.hu-berlin.de. 2. Klinik für Hals‑, Nasen‑, Ohrenheilkunde, BG Klinikum Unfallkrankenhaus Berlin gGmbH, Warener Str. 7, 12683, Berlin, Deutschland.
Abstract
BACKGROUND: A noise trauma induces central nervous system pathologies, which generate deficits in hearing and perception of sound. OBJECTIVE: Are degenerative mechanisms in the central auditory system a direct impact of overstimulation or an effect of acoustic deprivation? MATERIALS AND METHODS: Detection of cell death in a mouse model of noise-induced hearing loss at different times after single or repeated noise exposure. RESULTS: A single noise exposure (3 h, 115 dB SPL, 5-20 kHz) induces acute (≤1 day) and long-term (observation period 14 days) degeneration, particularly in subcortical structures. Repeated noise trauma is followed by pathologies in the auditory thalamus and cortex. CONCLUSION: Noise has a direct impact on basal structures of the central auditory system; a protection of cortical areas is possibly due to inhibitory neuronal projections. Degenerative mechanisms in higher structures of the pre-damaged system point to an increased impairment of complex processing of acoustic information.
BACKGROUND: A noise trauma induces central nervous system pathologies, which generate deficits in hearing and perception of sound. OBJECTIVE: Are degenerative mechanisms in the central auditory system a direct impact of overstimulation or an effect of acoustic deprivation? MATERIALS AND METHODS: Detection of cell death in a mouse model of noise-induced hearing loss at different times after single or repeated noise exposure. RESULTS: A single noise exposure (3 h, 115 dB SPL, 5-20 kHz) induces acute (≤1 day) and long-term (observation period 14 days) degeneration, particularly in subcortical structures. Repeated noise trauma is followed by pathologies in the auditory thalamus and cortex. CONCLUSION: Noise has a direct impact on basal structures of the central auditory system; a protection of cortical areas is possibly due to inhibitory neuronal projections. Degenerative mechanisms in higher structures of the pre-damaged system point to an increased impairment of complex processing of acoustic information.
Authors: Carol A Bauer; Jeremy G Turner; Donald M Caspary; Kristin S Myers; Thomas J Brozoski Journal: J Neurosci Res Date: 2008-08-15 Impact factor: 4.164