| Literature DB >> 2946416 |
K D Bloch, J G Seidman, J D Naftilan, J T Fallon, C E Seidman.
Abstract
The cellular mechanisms regulating secretion of the peptide hormone atrial natriuretic factor (ANF) differ in neonatal atrial and ventricular cardiocytes. We demonstrate that although both cell types synthesize and secrete ANF, only atrial cells store peptide in abundant secretory granules. Neonatal ventricular cells secrete ANF rapidly after synthesis and lack secretory granules. We propose that ventricular ANF is released by a constitutive secretory pathway whereas atrial ANF is stored and released by a regulated pathway. Furthermore, ventricular ANF mRNA and hormone concentrations decrease during the first week of life. Developmental variation in the use of ANF secretory pathways may reflect changing requirements for maintenance of intravascular volume and pressure. Tissue-specific modulation of hormone secretory pathways appears to be a novel response to developmentally induced changes in the requirements for a peptide hormone.Entities:
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Year: 1986 PMID： 2946416 DOI： 10.1016/0092-8674(86)90512-x
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582