| Literature DB >> 2946360 |
Abstract
In rats with unilateral 6-hydroxydopamine lesions of the substantia nigra, a specific D1 dopamine receptor agonist, SKF 38393A, at a dose that does not itself produce turning, significantly increased the contralateral rotation observed following a low dose of the specific D2 agonist LY 171555. Doses of SKF 38393A or the D2 agonist bromocriptine, which would themselves not induce turning, in combination produced a high rate of turning. These results suggest a synergistic interaction between D1 and D2 dopamine receptors in this system.Entities:
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Year: 1986 PMID： 2946360 DOI： 10.1016/0006-8993(86)91178-9
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252