Lucas S Broster1,2, Juan Li1,3, Benjamin Wagner1, Charles D Smith4,5,6, Gregory A Jicha4,5, Frederick A Schmitt2,4,5, Nancy Munro7, Ryan H Haney1, Yang Jiang1,5,6. 1. a Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA. 2. b Department of Psychiatry , University of California , San Francisco , CA , USA. 3. c Key Laboratory of Mental Health , Institute of Psychology, Chinese Academy of Sciences , Beijing , China. 4. d Department of Neurology , University of Kentucky College of Medicine , Lexington , KY , USA. 5. e Sanders-Brown Center on Aging , University of Kentucky College of Medicine , Lexington , KY , USA. 6. f Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine , Lexington , KY , USA. 7. g Oak Ridge National Laboratory , Oak Ridge , TN , USA.
Abstract
OBJECTIVE: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. METHOD: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. RESULTS: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. CONCLUSION: Visual cortex may play a role in maintained repetition effects in persons with early AD.
OBJECTIVE: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. METHOD:Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. RESULTS:Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. CONCLUSION: Visual cortex may play a role in maintained repetition effects in persons with early AD.
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