Literature DB >> 2946294

Hypoxia-induced release of atrial natriuretic factor (ANF) from the isolated rat and rabbit heart.

A J Baertschi, C Hausmaninger, R S Walsh, R M Mentzer, D A Wyatt, R A Pence.   

Abstract

The effect of hypoxia on the release of atrial natriuretic factor (ANF) was studied in isolated, constant-flow perfused hearts of rats and rabbits. Effluent samples were frozen pending extraction and radioimmunoassay of ANF. Hypoxia (10 min) caused a 3.9-fold (rats) and 4.6-fold (rabbits) increase of ANF release over control values. ANF release returned to control levels within 8-11 min of reoxygenation. Prolonged (20 min) hypoxia evoked further ANF release. The increase in ANF release and decrease in ventricular pressure, heart rate and coronary perfusion pressure were fully reversible, suggesting that tissues were not damaged. These results demonstrate that hypoxia induces a massive release of ANF by an as yet unexplained mechanism.

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Year:  1986        PMID： 2946294     DOI： 10.1016/0006-291x(86)91108-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

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2.  Massive atrial natriuretic peptide (ANP) release in ischemia reperfusion.

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3.  Sildenafil reverses the hypertrophy of mice right ventricle caused by hypoxia but does not reverse the changes in the myosin heavy chain isoforms.

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Review 5.  Physiology of natriuretic peptides: The volume overload hypothesis revisited.

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6.  The effects of chronic hypoxia on renal function in the rat.

Authors:  M Neylon; J M Marshall; E J Johns
Journal:  J Physiol       Date:  1997-05-15       Impact factor: 5.182

7.  Expression of the atrial natriuretic peptide gene in the cardiac muscle of rat extrapulmonary and intrapulmonary veins.

Authors:  D R Springall; M Bhatnagar; J Wharton; Q Hamid; S Gulbenkian; M Hedges; L Meleagros; S R Bloom; J M Polak
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9.  The effect of discrete stimulation of carotid body chemoreceptors on atrial natriuretic peptide in anaesthetized dogs.

Authors:  M al-Obaidi; E M Whitaker; F Karim
Journal:  J Physiol       Date:  1991-11       Impact factor: 5.182

10.  Normotensive normoxic men undergoing water diuresis fail to respond to stimulation of their peripheral arterial chemoreceptors by almitrine with an increase in plasma concentrations of atrial natriuretic factor.

Authors:  C Ledderhos; W Quies; A Bub; R Sanchez
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