Literature DB >> 29462679

Novel pH sensitive dual drug loaded-gelatin methacrylate/methacrylic acid hydrogel for the controlled release of antibiotics.

Thayyath Sreenivasan Anirudhan1, Anila Manasa Mohan2.   

Abstract

The aim of the present study was to develop a novel pH sensitive gelatin methacrylate hydrogel for the controlled delivery of Gentamicin (GS) and Ampicillin (Amp). GS and Amp having synergistic activity is effective in killing multi drug resistant bacteria. The hydrogel was well characterized using FTIR, XRD and SEM techniques. The drug loading and encapsulation efficiency were found to be 85.0 and 77.0% for GS, 79.0 and 88.0% for Amp, respectively. The in vitro swelling, degradation and release profiles suggest the pH dependent behaviour of hydrogel. DPPH Assay confirmed the role of 2-amino guanidine in nullifying the side effect of GS and inhibition percentage of DDLHG is found to be 85.0%. Antimicrobial studies revealed the increased efficiency of the drug combination in killing bacteria.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Combination therapy; Gelatin methacrylate; Gentamicin; Multi drug resistance; Polymer drug conjugate; Synergism

Mesh：

Substances：

Year:  2018        PMID： 29462679     DOI： 10.1016/j.ijbiomac.2018.01.220

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  5 in total

1.  In vivo Detection of Macromolecule Free Radicals in Mouse Sepsis-Associated Encephalopathy Using a New MRI and Immunospin Trapping Strategy.

Authors:  Hanrui Liu; Chengyong Ma; Huayan Xu; Huan Zhang; Rong Xu; Kun Zhang; Ran Sun; Kuan Li; Qihong Wu; Lingyi Wen; Lizhi Zhang; Yingkun Guo
Journal:  Int J Nanomedicine       Date:  2022-09-01

2.  Differential orientation and conformation of surface-bound keratinocyte growth factor on (hydroxyethyl)methacrylate, (hydroxyethyl)methacrylate/methyl methacrylate, and (hydroxyethyl)methacrylate/methacrylic acid hydrogel copolymers.

Authors:  Shohini Sen-Britain; Wesley L Hicks; Robert Hard; Joseph A Gardella
Journal:  Biointerphases       Date:  2018-10-25       Impact factor: 2.456

Review 3.  New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers.

Authors:  Cornelia Vasile; Daniela Pamfil; Elena Stoleru; Mihaela Baican
Journal:  Molecules       Date:  2020-03-27       Impact factor: 4.411

4.  Eudragit® L100/Polyvinyl Alcohol Nanoparticles Impregnated Mucoadhesive Films as Ocular Inserts for Controlled Delivery of Erythromycin: Development, Characterization and In Vivo Evaluation.

Authors:  Shahla Mirzaeei; Shiva Taghe; Raid G Alany; Ali Nokhodchi
Journal:  Biomedicines       Date:  2022-08-08

5.  Orally Administered, Biodegradable and Biocompatible Hydroxypropyl-β-Cyclodextrin Grafted Poly(methacrylic acid) Hydrogel for pH Sensitive Sustained Anticancer Drug Delivery.

Authors:  Nighat Batool; Rai Muhammad Sarfraz; Asif Mahmood; Muhammad Zaman; Nadiah Zafar; Ahmad Salawi; Yosif Almoshari; Meshal Alshamrani
Journal:  Gels       Date:  2022-03-19
  5 in total

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