Micaela Lugones1, Georgia Parkin1, Stefan Bjelosevic1, Michael Takagi2, Cathriona Clarke1, Vicki Anderson3, Vera Ignjatovic4. 1. Murdoch Children's Research Institute, Melbourne, Victoria, Australia. 2. Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Melbourne School of Psychological Sciences, University of Melbourne, Victoria, Australia. 3. Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Melbourne School of Psychological Sciences, University of Melbourne, Victoria, Australia; Psychology Service, The Royal Children's Hospital, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Victoria, Australia. 4. Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Paediatrics, University of Melbourne, Victoria, Australia. Electronic address: vera.ignjatovic@mcri.edu.au.
Abstract
OBJECTIVE: To summarize all current studies focusing on blood biomarkers in paediatric mild traumatic brain injury (mTBI) and to outline the possible use of blood biomarkers for diagnostic, prognostic and monitoring purposes within this setting. METHODS: A systematic review following the PRISMA guidelines was conducted using the MEDLINE, PubMed and EMBASE databases. RESULTS: A total of 21 studies were included in the review, encompassing a total of 14 different biomarkers. Seventeen (81%) of these studies found a significant association between biomarker concentration and mTBI characteristics, however results from studies to date are diverse and at times conflicting. CONCLUSION: GFAP appears to be a promising blood biomarker for the prognosis and monitoring of mTBI, whereas UCH-L1 appears more promising at mTBI diagnosis. Despite this, the overall heterogeneity in assessed biomarkers, study design and measurement tools has made drawing specific conclusions challenging. Future research will require more uniform study design and methodological approaches to allow for the comparison, corroboration and validation of blood biomarkers within the context of paediatric mTBI.
OBJECTIVE: To summarize all current studies focusing on blood biomarkers in paediatric mild traumatic brain injury (mTBI) and to outline the possible use of blood biomarkers for diagnostic, prognostic and monitoring purposes within this setting. METHODS: A systematic review following the PRISMA guidelines was conducted using the MEDLINE, PubMed and EMBASE databases. RESULTS: A total of 21 studies were included in the review, encompassing a total of 14 different biomarkers. Seventeen (81%) of these studies found a significant association between biomarker concentration and mTBI characteristics, however results from studies to date are diverse and at times conflicting. CONCLUSION:GFAP appears to be a promising blood biomarker for the prognosis and monitoring of mTBI, whereas UCH-L1 appears more promising at mTBI diagnosis. Despite this, the overall heterogeneity in assessed biomarkers, study design and measurement tools has made drawing specific conclusions challenging. Future research will require more uniform study design and methodological approaches to allow for the comparison, corroboration and validation of blood biomarkers within the context of paediatric mTBI.
Authors: William R McBride; Caroline E Conlan; Nicole A Barylski; Amelie C Warneryd; Randel L Swanson Journal: Curr Phys Med Rehabil Rep Date: 2022-02-26
Authors: Dibyadyuti Datta; Paul Bangirana; Robert O Opoka; Andrea L Conroy; Katrina Co; Caitlin Bond; Yi Zhao; Keisuke Kawata; Andrew J Saykin; Chandy C John Journal: JAMA Netw Open Date: 2021-12-01