R E Lemmetyinen1,2, J V Karjalainen3, A But2, R L O Renkonen1,4, J R Pekkanen2,5, S K Toppila-Salmi1,6, J K Haukka2. 1. Haartman Institute, Medicum, University of Helsinki, Helsinki, Finland. 2. Department of Public Health, University of Helsinki, Helsinki, Finland. 3. Allergy Centre, Tampere University Hospital, Tampere, Finland. 4. HUSLAB, Helsinki University Hospital, Helsinki, Finland. 5. Living Environment and Health Unit, National Institute for Health and Welfare, Kuopio, Finland. 6. Skin and Allergy Hospital, Hospital District of Helsinki and Uusimaa, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Abstract
BACKGROUND: Higher all-cause mortality in asthmatics has been shown previously. Polysensitization is associated with higher morbidity among asthmatic children, and allergic rhinitis and/or allergic conjunctivitis (AR/AC) are associated with higher morbidity in adult asthmatics. Little is known about the effect of AR/AC and other factors on mortality among adult asthmatics. The aim was to study mortality and its risk factors in adults with and without asthma. METHODS: We randomly selected 1648 asthmatics with age over 30 years from national registers and matched the asthma sample with one or two controls. Baseline information was obtained by a questionnaire in 1997, and the study population was linked with the death certificate information of Statistics Finland from 1997 to 2013. Overall and cause-specific survival between the groups was compared in several adjusted models. RESULTS: During a mean follow-up period of 15.6 years, 221 deaths among 1052 asthma patients and 335 deaths among 1889 nonasthmatics were observed. Cardiovascular diseases were the main cause of death in both groups. Asthma was associated with increased all-cause mortality (adjusted HR 1.25; 95% CI 1.05-1.49, P = .011) as well as mortality from chronic obstructive pulmonary disease (HR 12.0, 4.18-34.2, P < .001) and malignant neoplasms of respiratory organs (HR 2.33, 1.25-4.42, P = .008). Among asthmatics, smoking was associated with increased all-cause mortality, and self-reported AR/AC was associated with decreased mortality. Among nonasthmatics, smoking, and obesity were associated with increased all-cause mortality, whereas female gender showed an association with a decreased risk. CONCLUSIONS: Increased mortality among adult asthmatics was largely explained by the development of COPD, malignant respiratory tract neoplasms, and cardiovascular diseases. Smoking cessation is important for reduction in total mortality in both asthmatic and nonasthmatic adults. AR/AC was associated with decreased mortality only in asthmatics. Thus, studies in other populations of larger size are needed to explore further the nature of this association.
BACKGROUND: Higher all-cause mortality in asthmatics has been shown previously. Polysensitization is associated with higher morbidity among asthmatic children, and allergic rhinitis and/or allergic conjunctivitis (AR/AC) are associated with higher morbidity in adult asthmatics. Little is known about the effect of AR/AC and other factors on mortality among adult asthmatics. The aim was to study mortality and its risk factors in adults with and without asthma. METHODS: We randomly selected 1648 asthmatics with age over 30 years from national registers and matched the asthma sample with one or two controls. Baseline information was obtained by a questionnaire in 1997, and the study population was linked with the death certificate information of Statistics Finland from 1997 to 2013. Overall and cause-specific survival between the groups was compared in several adjusted models. RESULTS: During a mean follow-up period of 15.6 years, 221 deaths among 1052 asthmapatients and 335 deaths among 1889 nonasthmatics were observed. Cardiovascular diseases were the main cause of death in both groups. Asthma was associated with increased all-cause mortality (adjusted HR 1.25; 95% CI 1.05-1.49, P = .011) as well as mortality from chronic obstructive pulmonary disease (HR 12.0, 4.18-34.2, P < .001) and malignant neoplasms of respiratory organs (HR 2.33, 1.25-4.42, P = .008). Among asthmatics, smoking was associated with increased all-cause mortality, and self-reported AR/AC was associated with decreased mortality. Among nonasthmatics, smoking, and obesity were associated with increased all-cause mortality, whereas female gender showed an association with a decreased risk. CONCLUSIONS: Increased mortality among adult asthmatics was largely explained by the development of COPD, malignant respiratory tract neoplasms, and cardiovascular diseases. Smoking cessation is important for reduction in total mortality in both asthmatic and nonasthmatic adults. AR/AC was associated with decreased mortality only in asthmatics. Thus, studies in other populations of larger size are needed to explore further the nature of this association.
Authors: B Akinlade; E Guttman-Yassky; M de Bruin-Weller; E L Simpson; A Blauvelt; M J Cork; E Prens; P Asbell; E Akpek; J Corren; C Bachert; I Hirano; J Weyne; A Korotzer; Z Chen; T Hultsch; X Zhu; J D Davis; L Mannent; J D Hamilton; A Teper; H Staudinger; E Rizova; G Pirozzi; N M H Graham; B Shumel; M Ardeleanu; A Wollenberg Journal: Br J Dermatol Date: 2019-05-07 Impact factor: 9.302
Authors: Anu Laulajainen-Hongisto; Annina Lyly; Paula Kauppi; Sanna Toppila-Salmi; Tanzeela Hanif; Kishor Dhaygude; Matti Kankainen; Risto Renkonen; Kati Donner; Pirkko Mattila; Tuomas Jartti; Jean Bousquet Journal: Clin Transl Allergy Date: 2020-10-28 Impact factor: 5.871
Authors: Ashish Bansal; Eric L Simpson; Amy S Paller; Elaine C Siegfried; Andrew Blauvelt; Marjolein de Bruin-Weller; Jonathan Corren; Lawrence Sher; Emma Guttman-Yassky; Zhen Chen; Nadia Daizadeh; Mohamed A Kamal; Brad Shumel; Paola Mina-Osorio; Leda Mannent; Naimish Patel; Neil M H Graham; Faisal A Khokhar; Marius Ardeleanu Journal: Am J Clin Dermatol Date: 2021-01 Impact factor: 7.403
Authors: Riikka Lemmetyinen; Jussi Karjalainen; Anna But; Risto Renkonen; Juha Pekkanen; Jari Haukka; Sanna Toppila-Salmi Journal: BMJ Open Date: 2021-12-31 Impact factor: 2.692