Alfonso González1,2,3, Loreto Massardo1,2. 1. Facultad de Medicinay Ciencia, Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián. 2. Center for Aging and Regeneration (CARE), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. 3. Fundación Ciencia y Vida, Santiago, Chile.
Abstract
PURPOSE OF REVIEW: Analysis of antiribosomal P protein autoantibodies (anti-P) pathogenicity in diffuse brain manifestations of neuropsychiatric lupus, emphasizing cognitive dysfunction and the recently emerged role of cross-reacting neuronal surface P antigen (NSPA) in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and N-Methyl-D-Aspartate receptor glutamatergic transmission. RECENT FINDINGS: Circulating anti-P antibodies associate with executive planning dysfunction and attention impairments in lupus patients and perturb glutamatergic transmission through NSPA in mice hippocampus, translating into impaired synaptic plasticity and spatial memory. Planning impairment impacts quality of life. SUMMARY: In addition to the known association with lupus psychosis, new clinical and experimental evidence reveal a pathogenic role of anti-P antibodies in cognitive dysfunction, mechanistically explained by the anti-P interaction with NSPA as a target involved in glutamatergic synaptic plasticity.
PURPOSE OF REVIEW: Analysis of antiribosomal P protein autoantibodies (anti-P) pathogenicity in diffuse brain manifestations of neuropsychiatric lupus, emphasizing cognitive dysfunction and the recently emerged role of cross-reacting neuronal surface P antigen (NSPA) in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and N-Methyl-D-Aspartate receptor glutamatergic transmission. RECENT FINDINGS: Circulating anti-P antibodies associate with executive planning dysfunction and attention impairments in lupuspatients and perturb glutamatergic transmission through NSPA in mice hippocampus, translating into impaired synaptic plasticity and spatial memory. Planning impairment impacts quality of life. SUMMARY: In addition to the known association with lupus psychosis, new clinical and experimental evidence reveal a pathogenic role of anti-P antibodies in cognitive dysfunction, mechanistically explained by the anti-P interaction with NSPA as a target involved in glutamatergic synaptic plasticity.
Authors: Meggan Mackay; An Vo; Chris C Tang; Michael Small; Erik W Anderson; Elisabeth J Ploran; Justin Storbeck; Brittany Bascetta; Simran Kang; Cynthia Aranow; Carl Sartori; Philip Watson; Bruce T Volpe; Betty Diamond; David Eidelberg Journal: JCI Insight Date: 2019-01-10
Authors: J M Chi; M Mackay; A Hoang; K Cheng; C Aranow; J Ivanidze; B Volpe; B Diamond; P C Sanelli Journal: AJNR Am J Neuroradiol Date: 2019-02-21 Impact factor: 3.825
Authors: Elisabeth Ploran; Chris Tang; Meggan Mackay; Michael Small; Erik Anderson; Justin Storbeck; Brittany Bascetta; Simran Kang; Cynthia Aranow; Carl Sartori; Philip Watson; Bruce Volpe; Betty Diamond; David Eidelberg Journal: Lupus Sci Med Date: 2019-07-11
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