Hu Yue1,2, Liu Shan1, Lv Bin3,4. 1. Department of Gastroenterology, First Affiliated Hospital of Zhejiang, Chinese Medical University, 54 Youdian Road, Hangzhou, 310006, China. 2. Key Laboratory of Digestive Pathophysiology of Zhejiang Province, First Affiliated Hospital of Zhejiang, Chinese Medical University, 54 Youdian Road, Hangzhou, 310006, China. 3. Department of Gastroenterology, First Affiliated Hospital of Zhejiang, Chinese Medical University, 54 Youdian Road, Hangzhou, 310006, China. lvbin@medmail.com.cn. 4. Key Laboratory of Digestive Pathophysiology of Zhejiang Province, First Affiliated Hospital of Zhejiang, Chinese Medical University, 54 Youdian Road, Hangzhou, 310006, China. lvbin@medmail.com.cn.
Abstract
BACKGROUND: Despite extensive research on the criteria for the assessment of gastric cancer risk using the Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis/Intestinal-Metaplasia Assessment (OLGIM) systems, no comprehensive overview or systematic summary on their use is currently available. AIM: To perform a systematic review and meta-analysis to assess the efficacy of the OLGA and OLGIM staging systems in evaluating gastric cancer risk. METHODS: We searched various databases, including PubMed, EMBASE, Medline, and Cochrane's library, for articles published before March 2017 on the association between OLGA/OLGIM stages and risk of gastric cancer. Statistical analysis was performed using RevMan 5.30 and Stata 14.0, with the odds ratio, risk ratio, and 95% confidence interval as the effect measures. RESULTS: A meta-analysis of six case-control studies and two cohort studies, comprising 2700 subjects, was performed. The meta-analysis of prospective case-control studies demonstrated a significant association between the OLGA/OLGIM stages III/IV and gastric cancer. The Newcastle-Ottawa Scale (NOS) score reflected heterogeneity in the case-control studies on OLGA. Subgroup analysis of high-quality (NOS score ≥ 5) studies showed an association between OLGA stage III/IV and increased risk of gastric cancer; the association was also high in the remaining study with low NOS score. The association between higher stages of gastritis defined by OLGA and risk of gastric cancer was significant. CONCLUSIONS: This correlation implies that close and frequent monitoring of such high-risk patients is necessary to facilitate timely diagnosis of gastric cancer.
BACKGROUND: Despite extensive research on the criteria for the assessment of gastric cancer risk using the Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis/Intestinal-Metaplasia Assessment (OLGIM) systems, no comprehensive overview or systematic summary on their use is currently available. AIM: To perform a systematic review and meta-analysis to assess the efficacy of the OLGA and OLGIM staging systems in evaluating gastric cancer risk. METHODS: We searched various databases, including PubMed, EMBASE, Medline, and Cochrane's library, for articles published before March 2017 on the association between OLGA/OLGIM stages and risk of gastric cancer. Statistical analysis was performed using RevMan 5.30 and Stata 14.0, with the odds ratio, risk ratio, and 95% confidence interval as the effect measures. RESULTS: A meta-analysis of six case-control studies and two cohort studies, comprising 2700 subjects, was performed. The meta-analysis of prospective case-control studies demonstrated a significant association between the OLGA/OLGIM stages III/IV and gastric cancer. The Newcastle-Ottawa Scale (NOS) score reflected heterogeneity in the case-control studies on OLGA. Subgroup analysis of high-quality (NOS score ≥ 5) studies showed an association between OLGA stage III/IV and increased risk of gastric cancer; the association was also high in the remaining study with low NOS score. The association between higher stages of gastritis defined by OLGA and risk of gastric cancer was significant. CONCLUSIONS: This correlation implies that close and frequent monitoring of such high-risk patients is necessary to facilitate timely diagnosis of gastric cancer.
Entities:
Keywords:
Gastric cancer; Meta-analysis; Operative link on gastric intestinal metaplasia assessment stage; Operative link on gastritis assessment; Risk factors; Systematic review
Authors: Woon Geon Shin; Heung Up Kim; Ho June Song; Su Jin Hong; Ki-Nam Shim; In-Kyung Sung; Jae Gyu Kim Journal: Dig Dis Sci Date: 2011-10-08 Impact factor: 3.199
Authors: Lisette G Capelle; Annemarie C de Vries; Jelle Haringsma; Frank Ter Borg; Richard A de Vries; Marco J Bruno; Herman van Dekken; Jos Meijer; Nicole C T van Grieken; Ernst J Kuipers Journal: Gastrointest Endosc Date: 2010-04-09 Impact factor: 9.427
Authors: M Rugge; M de Boni; G Pennelli; M de Bona; L Giacomelli; M Fassan; D Basso; M Plebani; D Y Graham Journal: Aliment Pharmacol Ther Date: 2010-02-23 Impact factor: 8.171
Authors: S-J Cho; I J Choi; M-C Kook; B-H Nam; C G Kim; J Y Lee; K W Ryu; Y-W Kim Journal: Aliment Pharmacol Ther Date: 2013-10-06 Impact factor: 8.171
Authors: Jacques Ferlay; Isabelle Soerjomataram; Rajesh Dikshit; Sultan Eser; Colin Mathers; Marise Rebelo; Donald Maxwell Parkin; David Forman; Freddie Bray Journal: Int J Cancer Date: 2014-10-09 Impact factor: 7.396
Authors: Andrew J Gawron; Shailja C Shah; Osama Altayar; Perica Davitkov; Douglas Morgan; Kevin Turner; Reem A Mustafa Journal: Gastroenterology Date: 2019-12-06 Impact factor: 22.682
Authors: Osama Altayar; Perica Davitkov; Shailja C Shah; Andrew J Gawron; Douglas R Morgan; Kevin Turner; Reem A Mustafa Journal: Gastroenterology Date: 2019-12-06 Impact factor: 22.682
Authors: Alba Panarese; Giovanni Galatola; Raffaele Armentano; Pedro Pimentel-Nunes; Enzo Ierardi; Maria Lucia Caruso; Francesco Pesce; Marco Vincenzo Lenti; Valeria Palmitessa; Sergio Coletta; Endrit Shahini Journal: World J Gastroenterol Date: 2020-07-14 Impact factor: 5.742