| Literature DB >> 29459682 |
Lukas Reisky1, Hanna C Büchsenschütz1, Jennifer Engel1, Tao Song2, Thomas Schweder3, Jan-Hendrik Hehemann4,5, Uwe T Bornscheuer6.
Abstract
Sugar O-methylation shields algal polysaccharides against microbial hydrolytic enzymes. Here, we describe cytochrome P450 monooxygenases from marine bacteria that, together with appropriate redox-partner proteins, catalyze the oxidative demethylation of 6-O-methyl-D-galactose, which is an abundant monosaccharide of the algal polysaccharides agarose and porphyran. This previously unknown biological function extends the group of carbohydrate-active enzymes to include the class of cytochrome P450 monooxygenases.Entities:
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Year: 2018 PMID： 29459682 DOI： 10.1038/s41589-018-0005-8
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040