Heather Angus-Leppan1,2,3, Defne Saatci4, Alastair Sutcliffe4, Roberto J Guiloff5,6. 1. Clinical Neurosciences, Royal Free London NHS Foundation Trust, London NW3 2QG, UK heather.angus-leppan@nhs.net. 2. Institute of Neurology, University College London. 3. Centre for Research in Primary and Community Care, University of Hertfordshire, Hatfield, UK. 4. University College London and Great Ormond Street Institute of Child Health, University College London. 5. Imperial College London. 6. Faculty of Medicine, University of Chile, Santiago, Chile.