Mohammad Sadegh Ahmad Akhoundi1, Sedigheh Sheikhzadeh2, Amirhossein Mirhashemi3, Elahe Ansari3, Yasaman Kheirandish4, Mozhgan Allaedini1, Ahmadreza Dehpour1. 1. Dental Research Center Dentistry Research Institute, Orthodontics Department, Tehran University of Medical Sciences, Tehran, Iran. 2. Orthodontics Department, Dental faculty, Babol University of Medical Sciences, Babol, Iran. Electronic address: elfsh@yahoo.com. 3. Orthodontics Department, Dental faculty, Tehran University of Medical Sciences, Tehran, Iran. 4. Oral and Maxillofacial Radiology Department, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
PURPOSE: The aim of the present study was to evaluate the effect of the carbamazepine and valproic acid on orthodontic tooth movement in male Wistar rats. METHODS: Evaluation of tooth movement after 21 days of drugs infusion was carried out by feeler gauge. Bone densitometry on lateral cephalograms was conducted on days 1 and 21. After dissection of the maxillae, histologic parameters were evaluated. RESULTS: Orthodontic tooth movement was accelerated in experimental groups rather than controls. Optical density was significantly increased in these groups. In histologic sections, mesioapical portion of the PDL (Periodontal Ligament) was wider in experimental groups. Also, distoapical portion of the PDL was wider only in valproic acid group. CONCLUSION: Valproic acid and carbamazepine can decrease the bone density which may induce the accelerated orthodontic tooth movement in rats.
PURPOSE: The aim of the present study was to evaluate the effect of the carbamazepine and valproic acid on orthodontic tooth movement in male Wistar rats. METHODS: Evaluation of tooth movement after 21 days of drugs infusion was carried out by feeler gauge. Bone densitometry on lateral cephalograms was conducted on days 1 and 21. After dissection of the maxillae, histologic parameters were evaluated. RESULTS: Orthodontic tooth movement was accelerated in experimental groups rather than controls. Optical density was significantly increased in these groups. In histologic sections, mesioapical portion of the PDL (Periodontal Ligament) was wider in experimental groups. Also, distoapical portion of the PDL was wider only in valproic acid group. CONCLUSION:Valproic acid and carbamazepine can decrease the bone density which may induce the accelerated orthodontic tooth movement in rats.