Yong Won Cho1, Keun Tae Kim1, Hye-Jin Moon1,2, Valeriy R Korostyshevskiy3, Gholam K Motamedi4, Kwang Ik Yang5. 1. Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, South Korea. 2. Department of Neurology, School of Medicine, Soonchunhyang University, Bucheon, South Korea. 3. Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, Washington, DC. 4. Department of Neurology, Georgetown University Hospital, Washington, DC. 5. Sleep Disorders Center, Department of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, South Korea.
Abstract
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) and chronic insomnia are two common sleep disorders and both are considered independent risk factors for heart disease. The aim of this study was to investigate the prevalence of comorbid insomnia with OSA and to compare its clinical characteristics with those of OSA without insomnia. METHODS: Patients who visited two tertiary university hospital sleep centers were screened. Those with a diagnosis of OSA using polysomnography were divided into two groups based on their scores on the Korean version of the Insomnia Severity Index (ISI-K): OSA with insomnia (OSA+I) (ISI-K score ≥ 15) and OSA without insomnia (OSA-I) (ISI-K score < 15). Subjective symptoms were evaluated using sleep questionnaires including ISI-K. Demographic and clinical characteristics of OSA+I and OSA-I were compared. RESULTS: Out of 476 patients with OSA, 139 (29.2%) had significant insomnia. Patients in the OSA+I group had a higher percentage of females (35.3% versus 19.6%, P < .001) and have higher rates of heart disease (19.4% versus 8.6%, P < .001). OSA+I group showed lower quality of life, lower quality of sleep, higher sleep propensity, and higher depression as measured by the Korean versions of the Short-Form 36-Item Health Survey, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Beck Depression Inventory, respectively. There were no significant differences in adherence to continuous positive airway pressure between the groups. CONCLUSIONS: There is a high prevalence of comorbid insomnia with OSA (29.2%), consistent with previous findings in Western studies. Comorbid insomnia with OSA may constitute a cumulative risk factor for cardiovascular disease. These findings warrant further investigation into the mechanisms involved in its pathogenesis and devising more efficient treatments.
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) and chronic insomnia are two common sleep disorders and both are considered independent risk factors for heart disease. The aim of this study was to investigate the prevalence of comorbid insomnia with OSA and to compare its clinical characteristics with those of OSA without insomnia. METHODS:Patients who visited two tertiary university hospital sleep centers were screened. Those with a diagnosis of OSA using polysomnography were divided into two groups based on their scores on the Korean version of the Insomnia Severity Index (ISI-K): OSA with insomnia (OSA+I) (ISI-K score ≥ 15) and OSA without insomnia (OSA-I) (ISI-K score < 15). Subjective symptoms were evaluated using sleep questionnaires including ISI-K. Demographic and clinical characteristics of OSA+I and OSA-I were compared. RESULTS: Out of 476 patients with OSA, 139 (29.2%) had significant insomnia. Patients in the OSA+I group had a higher percentage of females (35.3% versus 19.6%, P < .001) and have higher rates of heart disease (19.4% versus 8.6%, P < .001). OSA+I group showed lower quality of life, lower quality of sleep, higher sleep propensity, and higher depression as measured by the Korean versions of the Short-Form 36-Item Health Survey, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Beck Depression Inventory, respectively. There were no significant differences in adherence to continuous positive airway pressure between the groups. CONCLUSIONS: There is a high prevalence of comorbid insomnia with OSA (29.2%), consistent with previous findings in Western studies. Comorbid insomnia with OSA may constitute a cumulative risk factor for cardiovascular disease. These findings warrant further investigation into the mechanisms involved in its pathogenesis and devising more efficient treatments.
Authors: Erla Björnsdóttir; Christer Janson; Thorarinn Gíslason; Jón F Sigurdsson; Allan I Pack; Philip Gehrman; Bryndís Benediktsdóttir Journal: J Sleep Res Date: 2011-10-12 Impact factor: 3.981
Authors: Vishesh K Kapur; Dennis H Auckley; Susmita Chowdhuri; David C Kuhlmann; Reena Mehra; Kannan Ramar; Christopher G Harrod Journal: J Clin Sleep Med Date: 2017-03-15 Impact factor: 4.062
Authors: Cathy A Alessi; Constance H Fung; Joseph M Dzierzewski; Lavinia Fiorentino; Carl Stepnowsky; Juan C Rodriguez Tapia; Yeonsu Song; Michelle R Zeidler; Karen Josephson; Michael N Mitchell; Stella Jouldjian; Jennifer L Martin Journal: Sleep Date: 2021-04-09 Impact factor: 5.849
Authors: Christopher C Imes; Zhadyra Bizhanova; Susan M Sereika; Mary T Korytkowski; Charles W Atwood; Lora E Burke; Jacob Kariuki; Jonna L Morris; Robert Stansbury; Patrick J Strollo; Eileen R Chasens Journal: Sleep Breath Date: 2021-06-09 Impact factor: 2.816
Authors: Alexander Sweetman; Leon Lack; R Doug McEvoy; Peter G Catcheside; Nick A Antic; Ching Li Chai-Coetzer; James Douglas; Amanda O'Grady; Nicola Dunn; Jan Robinson; Denzil Paul; Simon Smith Journal: J Clin Sleep Med Date: 2021-03-01 Impact factor: 4.062