| Literature DB >> 29457976 |
J S Dileep Kumar1, Kiran Kumar Solingapuram Sai2, Jaya Prabhakaran1,3, Hakeem R Oufkir2, Gayathri Ramanathan2, Christopher T Whitlow2, Hima Dileep1,3, Akiva Mintz2, J John Mann1,3.
Abstract
Abnormalities of microtubules (MTs) are implicated in the pathogenesis of many CNS diseases. Despite the potential of an MT imaging agents, no PET ligand is currently available for in vivo imaging of MTs in the brain. We radiolabeled [11C]MPC-6827, a high affinity MTA, and demonstrated its specific binding in rat and mice brain using PET imaging. Our experiments show that [11C]MPC-6827 has specific binding to MT in brain, and it is the first MT-binding PET ligand.Entities:
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Year: 2018 PMID： 29457976 PMCID： PMC6637745 DOI： 10.1021/acs.jmedchem.8b00028
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446