| Literature DB >> 29457930 |
Shunxiu Cao1, Jiamin Guo1, Yujing He2, Murad Alahdal1, Shanshan Tang1, Yuekui Zhao1, Zhaocong Yang1, Huashan Gao1, Wenjun Hu1, Hulin Jiang2, Lianju Qin3, Liang Jin1.
Abstract
The main challenge of anticancer drugs is poor tumor targeting. Now cellular carriers are widely investigated to deliver anticancer agents. As an ideal cellular candidate, human umbilical cord derived mesenchymal stem cells (hUC-MSCs) possess inherent tropism potential to tumor. Here, we constructed hUC-MSCs carrying transferrin-inspired-nanoparticles that contain doxorubicin(hUC-MSCs-Tf-inspired-NPs) to achieve enhanced anti-tumor efficacy and made an evaluation. Results represented that hUC-MSCs-Tf-inspired-NPs not only exhibit the controlled-release property of Tf-inspired-NPs, but also integrate tumor tropism and penetrative abilities of MSCs. The tumor volume of nude mice bearing breast cancer MCF-7 treated with hUC-MSCs-Tf-inspired-NPs, was remarkably reduced compared to those treated with free drug or Tf-inspired-NPs. Thus, Tf-inspired-NPs loaded hUC-MSCs have a potential to deliver anticancer drugs.Entities:
Keywords: doxorubicin; targeted delivery; Mesenchymal stem cells; artificial cells; breast cancer; nanoparticles
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Year: 2018 PMID： 29457930 DOI： 10.1080/21691401.2018.1434185
Source DB: PubMed Journal: Artif Cells Nanomed Biotechnol ISSN： 2169-1401 Impact factor: 5.678