| Literature DB >> 2945700 |
H G Hasenack, A M Bosch, K Käär.
Abstract
In a cross-over study with orally administered desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) and 3-keto-desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) in ten women under steady-state conditions, the serum levels of 3-keto-desogestrel were monitored by radioimmunoassay. No statistically significant differences between treatment groups were found with respect to the areas under the curve of the serum levels versus time (AUC), peak heights and peak times. The individual AUCs for 3-keto-desogestrel after dosing with desogestrel (plus EE) or 3-keto-desogestrel (plus EE) show a similar degree of variation. The biotransformation of desogestrel into 3-keto-desogestrel is rapid and appears not to be limited by the metabolic capacity of the normal liver.Entities:
Keywords: Biology; Contraception; Contraceptive Agents, Estrogen--administraction and dosage; Contraceptive Agents, Estrogen--analysis; Contraceptive Agents, Female; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents--administraction and dosage; Contraceptive Agents--analysis; Endocrine System; Ethinyl Estradiol--administraction and dosage; Ethinyl Estradiol--analysis; Examinations And Diagnoses; Family Planning; Hormones--analysis; Laboratory Examinations And Diagnoses; Metabolic Effects; Physiology; Reproductive Control Agents
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Year: 1986 PMID： 2945700 DOI： 10.1016/0010-7824(86)90047-8
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375