Literature DB >> 29456789

Novel Modifications of Glycopeptide Antibiotics via Total Synthesis.

David J Newman1.   

Abstract

Although vancomycin has been in clinical use since the late 1950s, resistance due to alteration in the target microbe's peptidoglycan can vary significantly, reducing its activity. Total synthesis of derivatives has now led to a molecule with very significant activity against resistant strains.

Entities:  

Year:  2018        PMID： 29456789      PMCID： PMC5807861          DOI： 10.1021/acsmedchemlett.8b00029

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  10 in total

1.  Antibiotic resistance is ancient.

Authors:  Vanessa M D'Costa; Christine E King; Lindsay Kalan; Mariya Morar; Wilson W L Sung; Carsten Schwarz; Duane Froese; Grant Zazula; Fabrice Calmels; Regis Debruyne; G Brian Golding; Hendrik N Poinar; Gerard D Wright
Journal:  Nature       Date:  2011-08-31       Impact factor: 49.962

2.  Total syntheses and initial evaluation of [Ψ[C(═S)NH]Tpg⁴]vancomycin, [Ψ[C(═NH)NH]Tpg⁴]vancomycin, [Ψ[CH₂NH]Tpg⁴]vancomycin, and their (4-chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics.

Authors:  Akinori Okano; Atsushi Nakayama; Kejia Wu; Erick A Lindsey; Alex W Schammel; Yiqing Feng; Karen C Collins; Dale L Boger
Journal:  J Am Chem Soc       Date:  2015-03-09       Impact factor: 15.419

3.  A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria.

Authors:  Jian Xie; Joshua G Pierce; Robert C James; Akinori Okano; Dale L Boger
Journal:  J Am Chem Soc       Date:  2011-08-16       Impact factor: 15.419

4.  Peripheral modifications of [Ψ[CH2NH]Tpg4]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics.

Authors:  Akinori Okano; Nicholas A Isley; Dale L Boger
Journal:  Proc Natl Acad Sci U S A       Date:  2017-05-30       Impact factor: 11.205

Review 5.  Total Syntheses of Vancomycin-Related Glycopeptide Antibiotics and Key Analogues.

Authors:  Akinori Okano; Nicholas A Isley; Dale L Boger
Journal:  Chem Rev       Date:  2017-04-24       Impact factor: 60.622

6.  Total synthesis of the ristocetin aglycon.

Authors:  Brendan M Crowley; Yoshiki Mori; Casey C McComas; Datong Tang; Dale L Boger
Journal:  J Am Chem Soc       Date:  2004-04-07       Impact factor: 15.419

7.  Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.

Authors:  Yi-Yun Liu; Yang Wang; Timothy R Walsh; Ling-Xian Yi; Rong Zhang; James Spencer; Yohei Doi; Guobao Tian; Baolei Dong; Xianhui Huang; Lin-Feng Yu; Danxia Gu; Hongwei Ren; Xiaojie Chen; Luchao Lv; Dandan He; Hongwei Zhou; Zisen Liang; Jian-Hua Liu; Jianzhong Shen
Journal:  Lancet Infect Dis       Date:  2015-11-19       Impact factor: 25.071

8.  The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.

Authors:  Dale L Boger
Journal:  J Org Chem       Date:  2017-10-13       Impact factor: 4.354

9.  Total synthesis of [Ψ[C(═NH)NH]Tpg(4)]vancomycin and its (4-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding.

Authors:  Akinori Okano; Atsushi Nakayama; Alex W Schammel; Dale L Boger
Journal:  J Am Chem Soc       Date:  2014-09-16       Impact factor: 15.419

10.  Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice.

Authors:  Catriona P Harkins; Bruno Pichon; Michel Doumith; Julian Parkhill; Henrik Westh; Alexander Tomasz; Herminia de Lencastre; Stephen D Bentley; Angela M Kearns; Matthew T G Holden
Journal:  Genome Biol       Date:  2017-07-20       Impact factor: 13.583
  10 in total
  2 in total

1.  Treating a Global Health Crisis with a Dose of Synthetic Chemistry.

Authors:  Melissa A Hardy; Brandon A Wright; J Logan Bachman; Timothy B Boit; Hannah M S Haley; Rachel R Knapp; Robert F Lusi; Taku Okada; Veronica Tona; Neil K Garg; Richmond Sarpong
Journal:  ACS Cent Sci       Date:  2020-06-30       Impact factor: 14.553

2.  Preparation of surface molecularly imprinted polymer and its application for the selective extraction of teicoplanin from water.

Authors:  Hao Zhou; Kanlin Peng; Yijuan Su; Xuqin Song; Jingli Qiu; Renping Xiong; Limin He
Journal:  RSC Adv       Date:  2021-04-13       Impact factor: 3.361
  2 in total

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