Maaike Van Den Houte1, Katleen Bogaerts2, Ilse Van Diest3, Jozef De Bie4, Philippe Persoons5, Lukas Van Oudenhove6, Omer Van den Bergh7. 1. Health Psychology, University of Leuven, Belgium; REVAL - Rehabilitation Research Center, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium. Electronic address: maaike.vandenhoute@kuleuven.be. 2. Health Psychology, University of Leuven, Belgium; REVAL - Rehabilitation Research Center, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium. Electronic address: katleen.bogaerts@kuleuven.be. 3. Health Psychology, University of Leuven, Belgium. Electronic address: ilse.vandiest@kuleuven.be. 4. Centre for Translational Psychological Research (TRACE), Hospital ZOL, Limburg, Genk, Belgium. Electronic address: Jozef.DeBie@zol.be. 5. Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium. Electronic address: philippe.persoons@kuleuven.be. 6. Laboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Belgium. Electronic address: lukas.vanoudenhove@kuleuven.be. 7. Health Psychology, University of Leuven, Belgium. Electronic address: omer.vandenbergh@ppw.kuleuven.be.
Abstract
OBJECTIVE: Dyspnea perception is distorted in patients with medically unexplained dyspnea. The goals of this study were 1) to replicate these results in patients with fibromyalgia and/or chronic fatigue syndrome (CFS), and 2) to investigate predictors of distorted symptom perception within the patient group, with a focus on negative affectivity (NA), psychiatric comorbidity and somatic symptom severity. METHODS: Seventy-three patients diagnosed with fibromyalgia and/or CFS and 38 healthy controls (HC) completed a rebreathing paradigm, consisting of a baseline (60s of room air), a rebreathing phase (150s, gradually increasing ventilation, partial pressure of CO2 in the blood, and self-reported dyspnea), and a recovery phase (150s of room air). Dyspnea, respiratory flow and FetCO2 levels were measured continuously. RESULTS: Patients reported more dyspnea than HC in the recovery phase (p=0.039), but no differences between patients and HC were found in the baseline (p=0.07) or rebreathing phase (p=0.17). No significant differences between patients and HC were found in physiological reactivity. Within the patient group, the effect in the recovery phase was predicted by somatic symptom severity (p=0.046), but not by negative affectivity or by the number of psychiatric comorbidities. CONCLUSION: This study extended earlier findings in patients with medically unexplained dyspnea to patients with fibromyalgia and CFS. This suggests that altered symptom perception is a non-symptom-specific mechanism underlying functional somatic syndromes in general, particularly in patients with high levels of somatic symptom severity. The results are discussed in a predictive coding framework of symptom perception.
OBJECTIVE:Dyspnea perception is distorted in patients with medically unexplained dyspnea. The goals of this study were 1) to replicate these results in patients with fibromyalgia and/or chronic fatigue syndrome (CFS), and 2) to investigate predictors of distorted symptom perception within the patient group, with a focus on negative affectivity (NA), psychiatric comorbidity and somatic symptom severity. METHODS: Seventy-three patients diagnosed with fibromyalgia and/or CFS and 38 healthy controls (HC) completed a rebreathing paradigm, consisting of a baseline (60s of room air), a rebreathing phase (150s, gradually increasing ventilation, partial pressure of CO2 in the blood, and self-reported dyspnea), and a recovery phase (150s of room air). Dyspnea, respiratory flow and FetCO2 levels were measured continuously. RESULTS:Patients reported more dyspnea than HC in the recovery phase (p=0.039), but no differences between patients and HC were found in the baseline (p=0.07) or rebreathing phase (p=0.17). No significant differences between patients and HC were found in physiological reactivity. Within the patient group, the effect in the recovery phase was predicted by somatic symptom severity (p=0.046), but not by negative affectivity or by the number of psychiatric comorbidities. CONCLUSION: This study extended earlier findings in patients with medically unexplained dyspnea to patients with fibromyalgia and CFS. This suggests that altered symptom perception is a non-symptom-specific mechanism underlying functional somatic syndromes in general, particularly in patients with high levels of somatic symptom severity. The results are discussed in a predictive coding framework of symptom perception.
Authors: Jeffrey A Sparks; Tracy J Doyle; Xintong He; Beatrice Pan; Christine Iannaccone; Michelle L Frits; Paul F Dellaripa; Ivan O Rosas; Bing Lu; Michael E Weinblatt; Nancy A Shadick; Elizabeth W Karlson Journal: ACR Open Rheumatol Date: 2019-03-15
Authors: Maaike Van Den Houte; Lukas Van Oudenhove; Ilse Van Diest; Katleen Bogaerts; Philippe Persoons; Jozef De Bie; Omer Van den Bergh Journal: Front Psychol Date: 2018-03-06