Literature DB >> 2945556

Inhibition of human renal epithelial Na+/Pi cotransport by phosphonoformic acid.

A N Yusufi, M Szczepanska-Konkel, S A Kempson, J A McAteer, T P Dousa.   

Abstract

Phosphonoformic acid was a potent competitive inhibitor of Na+/Pi cotransport by brush border membrane vesicles isolated from human renal cortex (Ki 31 microM). The Na+/Pi cotransport system in rat renal brush border membrane vesicles was much less sensitive to inhibition (Ki 210 microM). Na+/Pi cotransport by cultured cells derived from human renal cortex also was inhibited by phosphonoformic acid. Both in isolated membranes and cells the inhibition was dose-dependent, competitive, and specific for Pi. The effectiveness of phosphonoformic acid on Na+/Pi cotransport in human kidney suggests that its administration may be a useful maneuver to increase renal Pi excretion.

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Year:  1986        PMID： 2945556     DOI： 10.1016/s0006-291x(86)80044-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


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