Literature DB >> 29454745

New ADCY3 Variants Dance in Obesity Etiology.

Yan Tian1, Boqiang Peng2, Xianghui Fu3.   

Abstract

The genetic etiology for obesity-related traits remains elusive. Recent studies link novel ADCY3 variants to obesity and diabetes, and identify an important role of ADCY3-mediated signaling at neuronal primary cilia in the predisposition of obesity. These findings provide new information on obesity etiology and suggest potential anti-obesity therapeutic strategies.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ADCY3; MC4R; cAMP; diabetes; genetic mutations; obesity

Mesh：

Year:  2018        PMID： 29454745     DOI： 10.1016/j.tem.2018.02.004

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  8 in total

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Review 4.  Genetics of Severe Obesity.

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Authors:  Marco Sazzini; Paolo Abondio; Stefania Sarno; Guido Alberto Gnecchi-Ruscone; Matteo Ragno; Cristina Giuliani; Sara De Fanti; Claudia Ojeda-Granados; Alessio Boattini; Julien Marquis; Armand Valsesia; Jerome Carayol; Frederic Raymond; Chiara Pirazzini; Elena Marasco; Alberto Ferrarini; Luciano Xumerle; Sebastiano Collino; Daniela Mari; Beatrice Arosio; Daniela Monti; Giuseppe Passarino; Patrizia D'Aquila; Davide Pettener; Donata Luiselli; Gastone Castellani; Massimo Delledonne; Patrick Descombes; Claudio Franceschi; Paolo Garagnani
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7.  Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function.

Authors:  Haixia Xu; Xiao Du; Jia Xu; Yu Zhang; Yan Tian; Geng Liu; Xiuxuan Wang; Meilin Ma; Wenya Du; Yu Liu; Lunzhi Dai; Wendong Huang; Nanwei Tong; Yuquan Wei; Xianghui Fu
Journal:  PLoS Biol       Date:  2020-02-24       Impact factor: 8.029

8.  Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory.

Authors:  Juliette Salles; Sanaa Eddiry; Emmanuelle Lacassagne; Virginie Laurier; Catherine Molinas; Éric Bieth; Nicolas Franchitto; Jean-Pierre Salles; Maithé Tauber
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  8 in total

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