Peiwen Zhang1, Chen Yang2, Honghui Guo3, Jiaji Wang4, Shengqiang Lin5, Huamei Li5, Yan Yang6, Wenhua Ling7. 1. Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China. 2. Department of Physical Examination, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P. R. China. 3. Department of Nutrition, Henry Fok School of Food Science and Engineering, Shaoguan University, Shaoguan, Guangdong, P. R. China. 4. Department of Preventive Medicine, School of Public Health and General Medicine, Guangzhou Medical University, Guangzhou, P. R. China. 5. Lecong Community Health Service Center, Shunde District, Foshan, Guangdong, P. R. China. 6. Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China. Electronic address: yangyan3@mail.sysu.edu.cn. 7. Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, P. R. China. Electronic address: lingwh@mail.sysu.edu.cn.
Abstract
BACKGROUND: The use of coenzyme Q10 (CoQ10) as an adjuvant treatment with routine clinical therapy against metabolic diseases has shown benefit. However, the effect of CoQ10 as a primary preventive agent against cardiovascular diseases (CVDs) has not been well studied. OBJECTIVE: The objective of this study was to investigate the effect of CoQ10 on CVD risk factors in dyslipidemic patients. METHODS: In this randomized, double-blinded, placebo-controlled trial, 101 dyslipidemic subjects without taking any hypoglycemic or hypolipidemic drugs were administrated to 120 mg CoQ10 or placebo daily for 24 weeks. Anthropometric parameters, lipid and glycemic profile, biomarkers of inflammation, and antioxidant capacity were evaluated before and after 12 and 24 weeks of intervention. RESULTS:All 101 subjects were included in the analysis. On the 12th week, compared to placebo, CoQ10 supplementation decreased systolic (P = .010) and diastolic pressure (P = .001) and increased serum total antioxidant capacity (TAC; P = .003). On the 24th week, compared to placebo, CoQ10 supplementation further lowered blood pressure and TAC, reduced triglyceride (P = .020) and low-density lipoprotein cholesterol (P = .016), and increased ApoA-I (P < .001) while decreasing homeostasis model assessment of insulin resistance index (P = .009). Adjustment for change of physical activity and energy intake did not alter the effect of CoQ10 on the aforementioned parameters but led to significant decrease of non-high-density lipoprotein cholesterol in CoQ10 group compared to placebo (P = .031). CONCLUSIONS: Twenty-four-week treatment of CoQ10 ameliorates multiple CVD risk factors. The versatility and safety of CoQ10 makes it a potential candidate for the primary prevention of CVD.
RCT Entities:
BACKGROUND: The use of coenzyme Q10 (CoQ10) as an adjuvant treatment with routine clinical therapy against metabolic diseases has shown benefit. However, the effect of CoQ10 as a primary preventive agent against cardiovascular diseases (CVDs) has not been well studied. OBJECTIVE: The objective of this study was to investigate the effect of CoQ10 on CVD risk factors in dyslipidemic patients. METHODS: In this randomized, double-blinded, placebo-controlled trial, 101 dyslipidemic subjects without taking any hypoglycemic or hypolipidemic drugs were administrated to 120 mg CoQ10 or placebo daily for 24 weeks. Anthropometric parameters, lipid and glycemic profile, biomarkers of inflammation, and antioxidant capacity were evaluated before and after 12 and 24 weeks of intervention. RESULTS: All 101 subjects were included in the analysis. On the 12th week, compared to placebo, CoQ10 supplementation decreased systolic (P = .010) and diastolic pressure (P = .001) and increased serum total antioxidant capacity (TAC; P = .003). On the 24th week, compared to placebo, CoQ10 supplementation further lowered blood pressure and TAC, reduced triglyceride (P = .020) and low-density lipoprotein cholesterol (P = .016), and increased ApoA-I (P < .001) while decreasing homeostasis model assessment of insulin resistance index (P = .009). Adjustment for change of physical activity and energy intake did not alter the effect of CoQ10 on the aforementioned parameters but led to significant decrease of non-high-density lipoprotein cholesterol in CoQ10 group compared to placebo (P = .031). CONCLUSIONS: Twenty-four-week treatment of CoQ10 ameliorates multiple CVD risk factors. The versatility and safety of CoQ10 makes it a potential candidate for the primary prevention of CVD.
Authors: Francisco Miguel Gutierrez-Mariscal; Antonio Pablo Arenas-de Larriva; Laura Limia-Perez; Juan Luis Romero-Cabrera; Elena Maria Yubero-Serrano; Jose López-Miranda Journal: Int J Mol Sci Date: 2020-10-23 Impact factor: 5.923