Rei Kaneko1, Shojiro Sawada2, Ai Tokita1, Rieko Honkura1, Noriko Tamura1, Shinjiro Kodama1, Tomohito Izumi1, Kei Takahashi1, Kenji Uno1, Junta Imai1, Tetsuya Yamada1, Yukiya Miyachi3, Hideyuki Hasegawa4, Hiroshi Kanai5, Yasushi Ishigaki6, Hideki Katagiri7. 1. Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan. 2. Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: ssawada@med.tohoku.ac.jp. 3. Medical Systems Research and Development Center R&D Management Headquarters, FUJIFILM Corporation, Kaisei, Japan. 4. Graduate School of Science and Engineering, University of Toyama, Toyama, Japan. 5. Department of Electronic Engineering, Tohoku University Graduate School of Medicine, Sendai, Japan. 6. Department of Internal Medicine, Division of Diabetes and Endocrinology, Iwate Medical University Hospital, Morioka, Japan. 7. Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: katagiri@med.tohoku.ac.jp.
Abstract
AIMS: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. METHODS: This cross-sectional study enrolled 180 T2DM patients, who were classified as not having atherosclerosis according to the carotid intima-media thickness (IMT) criteria. We measured serum cystatin C, the estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR), and analyzed the associations between these markers and arterial wall elasticity (Eθ), IMT and the cardio-ankle velocity index. RESULTS: Multiple linear regression analyses revealed that cystatin C was significantly associated with Eθ, while neither eGFR nor ACR showed an association. Furthermore, among the examined atherosclerotic markers, Eθ was most reliably associated with cystatin C. Additionally, the association between cystatin C and Eθ disappeared in the low elasticity subgroup, which included subjects in whom no atherosclerotic changes had yet been initiated. CONCLUSIONS: In T2DM patients without apparent arterial wall thickening, cystatin C is strongly and independently associated with arterial wall elasticity, which reflects the degree of subclinical atherosclerosis. Thus, cystatin C is a potentially useful marker of early-stage atherosclerosis.
AIMS: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. METHODS: This cross-sectional study enrolled 180 T2DM patients, who were classified as not having atherosclerosis according to the carotid intima-media thickness (IMT) criteria. We measured serum cystatin C, the estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR), and analyzed the associations between these markers and arterial wall elasticity (Eθ), IMT and the cardio-ankle velocity index. RESULTS: Multiple linear regression analyses revealed that cystatin C was significantly associated with Eθ, while neither eGFR nor ACR showed an association. Furthermore, among the examined atherosclerotic markers, Eθ was most reliably associated with cystatin C. Additionally, the association between cystatin C and Eθ disappeared in the low elasticity subgroup, which included subjects in whom no atherosclerotic changes had yet been initiated. CONCLUSIONS: In T2DM patients without apparent arterial wall thickening, cystatin C is strongly and independently associated with arterial wall elasticity, which reflects the degree of subclinical atherosclerosis. Thus, cystatin C is a potentially useful marker of early-stage atherosclerosis.
Authors: Jie Li; Haiyan Shangguan; Xiaoqian Chen; Xiao Ye; Bin Zhong; Pen Chen; Yamei Wang; Bin Xin; Yan Bi; Dalong Zhu Journal: Open Life Sci Date: 2020-06-11 Impact factor: 0.938
Authors: Qing Yang; Mei Zhang; Peng Sun; Yanying Li; Huichao Xu; Kejun Wang; Hongshan Shen; Bo Ban; Fupeng Liu Journal: BMJ Open Diabetes Res Care Date: 2021-11