Kristina Tedroff1, Gustaf Befrits2, Carl Johan Tedroff3, Stefan Gantelius4. 1. Neuropediatric Unit Q202, Astrid Lindgren Children's Hospital, 171 76, Stockholm, Sweden; Neuropediatric Unit, Department of Women's and Children's Health, Q207, Karolinska Institutet, 171 76, Stockholm, Sweden. Electronic address: kristina.tedroff@ki.se. 2. Stockholm County Council, Magnus Ladulåsgatan 63A, 118 27, Stockholm, Sweden. Electronic address: gustaf.befrits@sll.se. 3. Neuropediatric Unit, Department of Women's and Children's Health, Q207, Karolinska Institutet, 171 76, Stockholm, Sweden. Electronic address: cjtedroff@gmail.com. 4. Pediatric Orthopedic Unit Q102, Astrid Lindgren Children's Hospital, 171 76, Stockholm, Sweden; Neuropediatric Unit, Department of Women's and Children's Health, Q207, Karolinska Institutet, 171 76, Stockholm, Sweden. Electronic address: stefan.gantelius@ki.se.
Abstract
BACKGROUND AND OBJECTIVES: Children with cerebral palsy (CP) are routinely treated with botulinum toxin A (BoNT-A). Two non dose-equivalent and differently priced products, Botox and Dysport are used. Depending on the conversion one of the products is considerably cheaper. However, the dose conversion factors studied to date have varied widely and relevant studies have not included children. Our objective here was to compare the efficacy and health economics of the switch from Botox to Dysport in children with CP when conversion was set to 1:2. Specifically were these treatments perceived as equivalent in terms of efficacy, duration and side-effects and were the drug cost lowered by using Dysport. METHODS: This prospective, real-world, cost-effectiveness population-based observational study included all children with CP, (n = 159) mean age 9.4 years (SD, 4.3), in the larger Stockholm area who received BoNT-A between September 1, 2014, and December 31, 2015. Parents reported the efficacy, duration and side-effects of previous treatment while physicians reported doses and goals set by children and parents for the present treatment. Drug acquisition costs were provided by county administrators. RESULTS: In connection with 341 visits caregivers reported comparable effects of similar duration with these products, with few, similar and transient side-effects. The drug-cost per treatment was 4029 SEK for Botox and 2380 SEK in the case of Dysport. CONCLUSION: When Botox was replaced by a two-fold higher Unit dose of Dysport (conversion 1:2) parents perceived the treatment of their children with CP to be equally effective while the cost was 41% lower according to procured prices.
BACKGROUND AND OBJECTIVES:Children with cerebral palsy (CP) are routinely treated with botulinum toxin A (BoNT-A). Two non dose-equivalent and differently priced products, Botox and Dysport are used. Depending on the conversion one of the products is considerably cheaper. However, the dose conversion factors studied to date have varied widely and relevant studies have not included children. Our objective here was to compare the efficacy and health economics of the switch from Botox to Dysport in children with CP when conversion was set to 1:2. Specifically were these treatments perceived as equivalent in terms of efficacy, duration and side-effects and were the drug cost lowered by using Dysport. METHODS: This prospective, real-world, cost-effectiveness population-based observational study included all children with CP, (n = 159) mean age 9.4 years (SD, 4.3), in the larger Stockholm area who received BoNT-A between September 1, 2014, and December 31, 2015. Parents reported the efficacy, duration and side-effects of previous treatment while physicians reported doses and goals set by children and parents for the present treatment. Drug acquisition costs were provided by county administrators. RESULTS: In connection with 341 visits caregivers reported comparable effects of similar duration with these products, with few, similar and transient side-effects. The drug-cost per treatment was 4029 SEK for Botox and 2380 SEK in the case of Dysport. CONCLUSION: When Botox was replaced by a two-fold higher Unit dose of Dysport (conversion 1:2) parents perceived the treatment of their children with CP to be equally effective while the cost was 41% lower according to procured prices.