| Literature DB >> 29451682 |
Federica M Marelli-Berg1, Maryam Jangani1.
Abstract
Dynamic reorganization of the cytoskeleton is essential for numerous cellular processes including leukocyte migration. This process presents a substantial bioenergetic challenge to migrating cells as actin polymerization is dependent on ATP hydrolysis. Hence, migrating cells must increase ATP production to meet the increased metabolic demands of cytoskeletal reorganization. Despite this long-standing evidence, the metabolic regulation of leukocyte motility and trafficking has only recently begun to be investigated. In this review, we will summarize current knowledge of the crosstalk between cell metabolism and the cytoskeleton in leukocytes, and discuss the concept that leukocyte metabolism may reprogram in response to migratory stimuli and the different environmental cues received during recirculation ultimately regulating leukocyte motility and migration. ©2018 Society for Leukocyte Biology.Entities:
Keywords: Cells: Dendritic; Cells: Monocytes/Macrophages; Cells: Neutrophils; Cells: T Lymphocytes; Molecules: Adhesion Molecules; Molecules: Chemokines; Molecules: Integrins; Molecules: Signaling Cascade; Process: Cell Trafficking/Adhesion
Mesh：
Year: 2018 PMID： 29451682 DOI： 10.1002/JLB.1MR1117-472R
Source DB: PubMed Journal: J Leukoc Biol ISSN： 0741-5400 Impact factor: 4.962