Literature DB >> 29451048

Impact of radon and combinatory radon/carbon dioxide spa on pain and hypertension: Results from the explorative RAD-ON01 study.

Paul F Rühle1, Gerhart Klein2,3, Tatiana Rung4, Hong Tiep Phan4, Claudia Fournier5, Rainer Fietkau1, Udo S Gaipl1, Benjamin Frey1.   

Abstract

OBJECTIVES: Therapies with low doses of radon have beneficial effects on patients suffering from chronic painful degenerative and inflammatory diseases. We already showed that this is accompanied by systemic immune modulations. We here focus on pain-reducing effects of very low doses of radon by adding carbon dioxide water and its impact on heart rate variability (HRV), blood pressure and free radicals.
METHODS: 97 of 103 patients receiving radon spa (1.200 Bq/l at 34 °C or 600 Bq/l, 1 g/l CO2 at 34 °C) were monitored before and at three different time points after therapy. Individual pain perception was analyzed and the capability to process radicals. At each time point, the hypertensive patients (n = 46) were examined over 24 h for blood pressure and HRV.
RESULTS: Long-term pain reduction was observed in the majority of patients. A modulation of superoxide dismutase was identified, presumably representing a priming effect for lowering radiation stress. Further, lowering of blood pressure, especially in those patients who additionally received carbon dioxide, was seen. Radon did in particular impact on HRV implying lasting relaxation effects.
CONCLUSION: Radon/carbon dioxide spa efficiently reduces pain. In particular, patients simultaneously suffering from painful and cardiovascular diseases should be treated by combination of radon and CO2.

Entities:  

Keywords:  Chronic painful musculoskeletal diseases; hypertension; pain reduction; radon/carbon dioxide spa; superoxide dismutase

Mesh:

Substances:

Year:  2018        PMID: 29451048     DOI: 10.1080/14397595.2018.1442640

Source DB:  PubMed          Journal:  Mod Rheumatol        ISSN: 1439-7595            Impact factor:   3.023


  10 in total

1.  Temporarily increased TGFβ following radon spa correlates with reduced pain while serum IL-18 is a general predictive marker for pain sensitivity.

Authors:  Miriam Kullmann; Paul F Rühle; Alexandra Harrer; Anna Donaubauer; Ina Becker; Renate Sieber; Gerhart Klein; Claudia Fournier; Rainer Fietkau; Udo S Gaipl; Benjamin Frey
Journal:  Radiat Environ Biophys       Date:  2018-11-19       Impact factor: 1.925

Review 2.  Head-out immersion in natural thermal mineral water for the management of hypertension: a review of randomized controlled trials.

Authors:  Dan Yuan; Zhao-Xia Yu; Wen Wang; Yu Chen
Journal:  Int J Biometeorol       Date:  2019-08-11       Impact factor: 3.787

3.  Endogenous anandamide and self-reported pain are significantly reduced after a 2-week multimodal treatment with and without radon therapy in patients with knee osteoarthritis: a pilot study.

Authors:  M Gaisberger; J Fuchs; M Riedl; S Edtinger; R Reischl; G Grasmann; B Hölzl; F Landauer; H Dobias; F Eckstein; M Offenbächer; M Ritter; M Winklmayr
Journal:  Int J Biometeorol       Date:  2021-03-01       Impact factor: 3.787

4.  Effects of Radon From Hot Springs on Lymphocyte Subsets in Peripheral Blood.

Authors:  Chunnan Piao; Mei Tian; Hongjun Gao; Yanxiao Gao; Jianlei Ruan; Lina Wu; Gang Gao; Lirong Yi; Jianxiang Liu
Journal:  Dose Response       Date:  2020-02-03       Impact factor: 2.658

Review 5.  Radon Exposure-Therapeutic Effect and Cancer Risk.

Authors:  Andreas Maier; Julia Wiedemann; Felicitas Rapp; Franziska Papenfuß; Franz Rödel; Stephanie Hehlgans; Udo S Gaipl; Gerhard Kraft; Claudia Fournier; Benjamin Frey
Journal:  Int J Mol Sci       Date:  2020-12-30       Impact factor: 5.923

Review 6.  The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts.

Authors:  Anna-Jasmina Donaubauer; Lisa Deloch; Ina Becker; Rainer Fietkau; Benjamin Frey; Udo S Gaipl
Journal:  Int J Mol Sci       Date:  2020-09-02       Impact factor: 5.923

7.  ROS- and Radiation Source-Dependent Modulation of Leukocyte Adhesion to Primary Microvascular Endothelial Cells.

Authors:  Denise Eckert; Felicitas Rapp; Ayele T Tsedeke; Jessica Molendowska; Robert Lehn; Markus Langhans; Claudia Fournier; Franz Rödel; Stephanie Hehlgans
Journal:  Cells       Date:  2021-12-27       Impact factor: 6.600

8.  Radon Improves Clinical Response in an Animal Model of Rheumatoid Arthritis Accompanied by Increased Numbers of Peripheral Blood B Cells and Interleukin-5 Concentration.

Authors:  Lisa Deloch; Stephanie Hehlgans; Michael Rückert; Andreas Maier; Annika Hinrichs; Ann-Sophie Flohr; Denise Eckert; Thomas Weissmann; Michaela Seeling; Falk Nimmerjahn; Rainer Fietkau; Franz Rödel; Claudia Fournier; Benjamin Frey; Udo S Gaipl
Journal:  Cells       Date:  2022-02-16       Impact factor: 6.600

9.  Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model.

Authors:  Takahiro Kataoka; Shota Naoe; Kaito Murakami; Ryohei Yukimine; Yuki Fujimoto; Norie Kanzaki; Akihiro Sakoda; Fumihiro Mitsunobu; Kiyonori Yamaoka
Journal:  J Clin Biochem Nutr       Date:  2021-11-26       Impact factor: 3.114

10.  Sustained improvements in EQ-5D utility scores and self-rated health status in patients with ankylosing spondylitis after spa treatment including low-dose radon - an analysis of prospective radon indication registry data.

Authors:  Markus Ritter; Bertram Hölzl; Martin Gaisberger; Antje van der Zee-Neuen; Victoria Strobl; Heidemarie Dobias; Julia Fuchs; Johannes Untner; Wolfgang Foisner; Martina Knapp; Sebastian Edtinger; Martin Offenbächer
Journal:  BMC Musculoskelet Disord       Date:  2022-08-03       Impact factor: 2.562

  10 in total

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