D Toliczenko-Bernatowicz1, E Matuszczak2, M Tylicka3, A Sankiewicz4, M Komarowska1, E Gorodkiewicz4, W Debek1, A Hermanowicz1. 1. Paediatric Surgery Department, Medical University of Bialystok, Waszyngtona 17, 15-274, Bialystok, Poland. 2. Paediatric Surgery Department, Medical University of Bialystok, Waszyngtona 17, 15-274, Bialystok, Poland. ewamat@tlen.pl. 3. Biophysics Department, Medical University of Bialystok, Bialystok, Poland. 4. Electrochemistry Department, University of Bialystok, Bialystok, Poland.
Abstract
PURPOSE: To evaluate the concentration of 20S proteasome in the blood plasma of boys with cryptorchidism. METHODS: Patients-50 boys aged 1-4 years (median = 2.4 years) with unilateral cryptorchidism. The control group-50 healthy, age-matched boys (aged 1-4 years, median = 2.1 years), admitted for planned herniotomy. In our study, we used a novel technique Surface PLASMON RESONANCE Imaging. RESULTS: The median concentration of 20S proteasome in the blood plasma of boys with cryptorchidism was 2.5-fold higher than in boys with inguinal hernia. We noticed statistically significant difference between 20S proteasome levels in boys with cryptorchidism up to 2 years old and above 2 years old. CONCLUSIONS: We believe that the 20S proteasome concentrations in the blood plasma of boys with cryptorchidism reflect the heat-induced apoptosis of germ cells.
PURPOSE: To evaluate the concentration of 20S proteasome in the blood plasma of boys with cryptorchidism. METHODS:Patients-50 boys aged 1-4 years (median = 2.4 years) with unilateral cryptorchidism. The control group-50 healthy, age-matched boys (aged 1-4 years, median = 2.1 years), admitted for planned herniotomy. In our study, we used a novel technique Surface PLASMON RESONANCE Imaging. RESULTS: The median concentration of 20S proteasome in the blood plasma of boys with cryptorchidism was 2.5-fold higher than in boys with inguinal hernia. We noticed statistically significant difference between 20S proteasome levels in boys with cryptorchidism up to 2 years old and above 2 years old. CONCLUSIONS: We believe that the 20S proteasome concentrations in the blood plasma of boys with cryptorchidism reflect the heat-induced apoptosis of germ cells.
Authors: Kwon-Yul Ryu; Shamim A Sinnar; Laura G Reinholdt; Sergio Vaccari; Susan Hall; Manuel A Garcia; Tatiana S Zaitseva; Donna M Bouley; Kim Boekelheide; Mary Ann Handel; Marco Conti; Ron R Kopito Journal: Mol Cell Biol Date: 2007-12-10 Impact factor: 4.272