Literature DB >> 29450765

Impact of platelet reactivity on 5-year clinical outcomes following percutaneous coronary intervention: a landmark analysis.

Fabio Mangiacapra1, Iginio Colaiori2, Elisabetta Ricottini2, Antonio Creta2, Giuseppe Di Gioia2, Ilaria Cavallari2, Edoardo Bressi2, Marialessia Capuano2, Emanuele Barbato3,4, Germano Di Sciascio2.   

Abstract

We investigated the impact of suboptimal platelet reactivity on clinical outcomes after percutaneous coronary intervention (PCI). We enrolled 500 patients with stable coronary artery disease undergoing elective PCI. Platelet reactivity was measured before PCI using the VerifyNow P2Y12 assay. Primary endpoint was the incidence of ischemic or bleeding events at 1 month and 5 years. Patients with high platelet reactivity (HPR) showed significantly higher rates of ischemic events both during the 1st month after PCI (HR 2.06, 95% CI 1.02-4.06), and beyond 1 month compared with patients without HPR (HR 1.73, 95% CI 1.02-2.95). Conversely, compared with patients without low platelet reactivity (LPR), patients with LPR presented significantly higher rates of bleeding only during the 1st month (HR 3.67, 95% CI 1.68-8.02). In conclusion, pre-procedural HPR is associated with ischemic events even beyond the 1st month after PCI. The association of LPR with bleeding events seems to be confined to the periprocedural period.

Entities:  

Keywords:  Coronary artery disease; Percutaneous coronary intervention; Platelet function test

Mesh：

Substances：

Year:  2018        PMID： 29450765     DOI： 10.1007/s11239-018-1630-5

Source DB:  PubMed          Journal:  J Thromb Thrombolysis        ISSN： 0929-5305            Impact factor:   2.300


  26 in total

1.  Third universal definition of myocardial infarction.

Authors:  Kristian Thygesen; Joseph S Alpert; Allan S Jaffe; Maarten L Simoons; Bernard R Chaitman; Harvey D White; Kristian Thygesen; Joseph S Alpert; Harvey D White; Allan S Jaffe; Hugo A Katus; Fred S Apple; Bertil Lindahl; David A Morrow; Bernard R Chaitman; Peter M Clemmensen; Per Johanson; Hanoch Hod; Richard Underwood; Jeroen J Bax; Jeroen J Bonow; Fausto Pinto; Raymond J Gibbons; Keith A Fox; Dan Atar; L Kristin Newby; Marcello Galvani; Christian W Hamm; Barry F Uretsky; Ph Gabriel Steg; William Wijns; Jean-Pierre Bassand; Phillippe Menasche; Jan Ravkilde; E Magnus Ohman; Elliott M Antman; Lars C Wallentin; Paul W Armstrong; Maarten L Simoons; James L Januzzi; Markku S Nieminen; Mihai Gheorghiade; Gerasimos Filippatos; Russell V Luepker; Stephen P Fortmann; Wayne D Rosamond; Dan Levy; David Wood; Sidney C Smith; Dayi Hu; Jose-Luis Lopez-Sendon; Rose Marie Robertson; Douglas Weaver; Michal Tendera; Alfred A Bove; Alexander N Parkhomenko; Elena J Vasilieva; Shanti Mendis; Jeroen J Bax; Helmut Baumgartner; Claudio Ceconi; Veronica Dean; Christi Deaton; Robert Fagard; Christian Funck-Brentano; David Hasdai; Arno Hoes; Paulus Kirchhof; Juhani Knuuti; Philippe Kolh; Theresa McDonagh; Cyril Moulin; Bogdan A Popescu; Zeljko Reiner; Udo Sechtem; Per Anton Sirnes; Michal Tendera; Adam Torbicki; Alec Vahanian; Stephan Windecker; Joao Morais; Carlos Aguiar; Wael Almahmeed; David O Arnar; Fabio Barili; Kenneth D Bloch; Ann F Bolger; Hans Erik Botker; Biykem Bozkurt; Raffaele Bugiardini; Christopher Cannon; James de Lemos; Franz R Eberli; Edgardo Escobar; Mark Hlatky; Stefan James; Karl B Kern; David J Moliterno; Christian Mueller; Aleksandar N Neskovic; Burkert Mathias Pieske; Steven P Schulman; Robert F Storey; Kathryn A Taubert; Pascal Vranckx; Daniel R Wagner
Journal:  J Am Coll Cardiol       Date:  2012-09-05       Impact factor: 24.094

2.  Clopidogrel Versus Ticagrelor for Antiplatelet Maintenance in Diabetic Patients Treated With Percutaneous Coronary Intervention: Results of the CLOTILDIA Study (Clopidogrel High Dose Versus Ticagrelor for Antiplatelet Maintenance in Diabetic Patients).

Authors:  Fabio Mangiacapra; Elena Panaioli; Iginio Colaiori; Elisabetta Ricottini; Angelo Lauria Pantano; Paolo Pozzilli; Emanuele Barbato; Germano Di Sciascio
Journal:  Circulation       Date:  2016-09-13       Impact factor: 29.690

Review 3.  Bleeding and stent thrombosis on P2Y12-inhibitors: collaborative analysis on the role of platelet reactivity for risk stratification after percutaneous coronary intervention.

Authors:  Dániel Aradi; Ajay Kirtane; Laurent Bonello; Paul A Gurbel; Udaya S Tantry; Kurt Huber; Matthias K Freynhofer; Jurrien ten Berg; Paul Janssen; Dominick J Angiolillo; Jolanta M Siller-Matula; Rossella Marcucci; Giuseppe Patti; Fabio Mangiacapra; Marco Valgimigli; Olivier Morel; Tullio Palmerini; Matthew J Price; Thomas Cuisset; Adnan Kastrati; Gregg W Stone; Dirk Sibbing
Journal:  Eur Heart J       Date:  2015-04-20       Impact factor: 29.983

4.  Incremental Value of Platelet Reactivity Over a Risk Score of Clinical and Procedural Variables in Predicting Bleeding After Percutaneous Coronary Intervention via the Femoral Approach: Development and Validation of a New Bleeding Risk Score.

Authors:  Fabio Mangiacapra; Elisabetta Ricottini; Emanuele Barbato; Chiara Demartini; Aaron Peace; Giuseppe Patti; Vincenzo Vizzi; Bernard De Bruyne; William Wijns; Germano Di Sciascio
Journal:  Circ Cardiovasc Interv       Date:  2015-05       Impact factor: 6.546

5.  Relationship between peripheral arterial reactive hyperemia and residual platelet reactivity after 600 mg clopidogrel.

Authors:  Michalis Hamilos; Olivier Muller; Argyrios Ntalianis; Catalina Trana; Jozef Bartunek; Giovanna Sarno; Fabio Mangiacapra; Karen Dierickx; Peter Meeus; Thomas Cuisset; Bernard De Bruyne; William Wijns; Emanuele Barbato
Journal:  J Thromb Thrombolysis       Date:  2011-07       Impact factor: 2.300

6.  Long-term use of ticagrelor in patients with prior myocardial infarction.

Authors:  Marc P Bonaca; Deepak L Bhatt; Marc Cohen; Philippe Gabriel Steg; Robert F Storey; Eva C Jensen; Giulia Magnani; Sameer Bansilal; M Polly Fish; Kyungah Im; Olof Bengtsson; Ton Oude Ophuis; Andrzej Budaj; Pierre Theroux; Mikhail Ruda; Christian Hamm; Shinya Goto; Jindrich Spinar; José Carlos Nicolau; Robert G Kiss; Sabina A Murphy; Stephen D Wiviott; Peter Held; Eugene Braunwald; Marc S Sabatine
Journal:  N Engl J Med       Date:  2015-03-14       Impact factor: 91.245

7.  High residual platelet reactivity after clopidogrel: extent of coronary atherosclerosis and periprocedural myocardial infarction in patients with stable angina undergoing percutaneous coronary intervention.

Authors:  Fabio Mangiacapra; Bernard De Bruyne; Olivier Muller; Catalina Trana; Argyrios Ntalianis; Jozef Bartunek; Guy Heyndrickx; Germano Di Sciascio; William Wijns; Emanuele Barbato
Journal:  JACC Cardiovasc Interv       Date:  2010-01       Impact factor: 11.195

8.  Isolated elevation in troponin T after percutaneous coronary intervention is associated with higher long-term mortality.

Authors:  Abhiram Prasad; Mandeep Singh; Amir Lerman; Ryan J Lennon; David R Holmes; Charanjit S Rihal
Journal:  J Am Coll Cardiol       Date:  2006-10-17       Impact factor: 24.094

Review 9.  Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives.

Authors:  Dominick J Angiolillo; Antonio Fernandez-Ortiz; Esther Bernardo; Fernando Alfonso; Carlos Macaya; Theodore A Bass; Marco A Costa
Journal:  J Am Coll Cardiol       Date:  2007-03-26       Impact factor: 24.094

10.  Thrombolysis in Myocardial Infarction (TIMI) Trial--phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase.

Authors:  A K Rao; C Pratt; A Berke; A Jaffe; I Ockene; T L Schreiber; W R Bell; G Knatterud; T L Robertson; M L Terrin
Journal:  J Am Coll Cardiol       Date:  1988-01       Impact factor: 24.094
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  2 in total

1.  Circadian variations of platelet reactivity on clopidogrel in patients treated with elective percutaneous coronary intervention.

Authors:  Michele Mattia Viscusi; Fabio Mangiacapra; Simone Circhetta; Luca Paolucci; Roberta De Luca; Annunziata Nusca; Rosetta Melfi; Elisabetta Ricottini; Gian Paolo Ussia; Francesco Grigioni
Journal:  J Thromb Thrombolysis       Date:  2022-04-21       Impact factor: 2.300

2.  Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention.

Authors:  Edoardo Bressi; Fabio Mangiacapra; Elisabetta Ricottini; Ilaria Cavallari; Iginio Colaiori; Giuseppe Di Gioia; Antonio Creta; Marialessia Capuano; Michele Mattia Viscusi; Germano Di Sciascio
Journal:  J Cardiovasc Transl Res       Date:  2018-10-01       Impact factor: 4.132
  2 in total

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