Complications of combined retinal and retinal pigment epithelium hamartoma involving the optic disc in a child, treated with Avastin - a review of the literature and case presentation.

We present a case of a 9 years old boy, followed up for 4 years, with bilateral combined pigmented epithelial and retinal hamartoma, complicated with recurrent vitreous hemorrhages in one eye and neovascular glaucoma and cataract in the other eye, treated with repeated intravitreal injections of Bevacizumab. A review of the literature suggested that such lesions may be symptomatic because of decreased vision, macular pucker, strabismus and vitreous hemorrhages. This particular compressive, bilateral form of hamartoma of the optic nerve has not previously been reported as a cause for such an ischemic syndrome, complicated with neovascular glaucoma and cataract.