| Literature DB >> 29448848 |
Manpreet Singh1, Vandana Thakur1, Rahul Deshmukh2, Amit Sharma3, M S Rathore3, Ajay Kumar4, Neeraj Mishra1.
Abstract
The aim of this study was to prepare and characterise oral delivery of morin hydrate-loaded micellar nanocarriers using Pluronic P127 and Pluronic F123 for the effective management of Alzheimer's disease. After administration of formulation brain and blood drug concentration were found to be highest for optimised morin hydrate-loaded micellar nanocarriers as compared to plain morin hydrate. Significant (p < 0.05) reduction in assessed pharmacodynamic parameters was observed after administration of morin hydrate-loaded micellar nanocarriers as compared to disease control group. Chronic treatment with morin-loaded micelles significantly increased the memory in AlCl3 induced Alzheimer's disease in Wistar rats.Entities:
Keywords: Alzheimer’s disease; Blood–brain barrier; Micelles; Pluronic block polymers; critical micelle concentration
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Year: 2018 PMID： 29448848 DOI： 10.1080/02652048.2018.1441916
Source DB: PubMed Journal: J Microencapsul ISSN： 0265-2048 Impact factor: 3.142