| Literature DB >> 2944864 |
S H Silverman, M Johnson, D W Burdon, M R Keighley.
Abstract
The pharmacokinetics of single dose intravenous ciprofloxacin in patients undergoing gastrointestinal surgery (100 mg, n = 8; 200 mg n = 18) have been studied. Following 100 mg therapeutic serum levels were maintained for approximately 40 min only and tissue concentrations were frequently less than 0.15 mg/kg. 200 mg maintained therapeutic serum levels for at least 150 min and produced mean concentrations in fat, muscle, peritoneum and gut wall of 1.04, 1.94, 1.59, and 3.39 mg/kg respectively. 200 mg iv ciprofloxacin would appear to provide adequate serum and tissue concentrations for at least 150 min.Entities:
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Year: 1986 PMID： 2944864 DOI： 10.1093/jac/18.1.107
Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790