Literature DB >> 2944750

Pharmacological characterization of release-regulating serotonin autoreceptors in rat cerebellum.

G Bonanno, G Maura, M Raiteri.   

Abstract

The release of [3H]5-hydroxytryptamine ([3H]5-HT) evoked by 15 mM KCl in superfused rat cerebellum synaptosomes was inhibited by 5-HT (pEC30 = 8.73). Methiothepin antagonized 5-HT (pA2 = 9.28); ketanserin, methysergide, cinanserin and spiperone were ineffective. The receptors involved were activated (pEC30 = 8.90) by the 5-HT1 agonist 5-methoxy-3-[1,2,3,6-tetrahydropyridin-4-yl]-1H-indole (RU 24969) X (-)Propranolol shifted to the right (pA2 = 8.05) the dose-response curve of 5-HT. The 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was ineffective. In conclusion, autoreceptors are present on 5-HT nerve endings in rat cerebellum and appear to belong to the 5-HT1B subtype.

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Year:  1986        PMID： 2944750     DOI： 10.1016/0014-2999(86)90065-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain.

Authors:  P C Waldmeier; M Williams; P A Baumann; S Bischoff; M A Sills; R F Neale
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-06       Impact factor: 3.000

2.  The pharmacological properties of the presynaptic serotonin autoreceptor in the pig brain cortex conform to the 5-HT1D receptor subtype.

Authors:  E Schlicker; K Fink; M Göthert; D Hoyer; G Molderings; I Roschke; P Schoeffter
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-07       Impact factor: 3.000

3.  Endogenous agonists may change the concentration-response curves of exogenous agonists: source of quantitative information about the endogenous tone.

Authors:  T J Feuerstein; J Bammert; D K Meyer
Journal:  Biol Cybern       Date:  1987       Impact factor: 2.086

4.  Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain.

Authors:  L Rényi; L G Larsson; S Berg; B E Svensson; G Thorell; S B Ross
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-01       Impact factor: 3.000

5.  Release-regulating autoreceptors of the GABAB-type in human cerebral cortex.

Authors:  G Bonanno; P Cavazzani; G C Andrioli; D Asaro; G Pellegrini; M Raiteri
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739

6.  Estimation of pA2 values at presynaptic alpha 2-autoreceptors in rabbit and rat brain cortex in the absence of autoinhibition.

Authors:  N Limberger; A Mayer; G Zier; B Valenta; K Starke; E A Singer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-12       Impact factor: 3.000

7.  Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex.

Authors:  N Limberger; R Deicher; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-04       Impact factor: 3.000

8.  Serotonin autoreceptor in rat hippocampus: pharmacological characterization as a subtype of the 5-HT1 receptor.

Authors:  G Maura; E Roccatagliata; M Raiteri
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-12       Impact factor: 3.000

9.  Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice.

Authors:  A Lecci; F Borsini; A Mancinelli; V D'Aranno; M A Stasi; G Volterra; A Meli
Journal:  J Neural Transm Gen Sect       Date:  1990

10.  Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine.

Authors:  D G Spencer; T Glaser; J Traber
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  10 in total

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