Yue Wu1, Xiao-Ni Wang2,3, Ningli Wang4, Ying Han2,3, Daqing Ma5, Yan Lu1. 1. a Department of Ophthalmology , Beijing Shijitan Hospital, Capital Medical University , Beijing , China. 2. b Department of Neurology , Xuan Wu Hospital of Capital Medical University , Beijing , China. 3. c Center of Alzheimer's Disease , Beijing Institute for Brain Disorders , Beijing , China. 4. d Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center , Beijing Tongren Hospital, Capital Medical University , Beijing , China. 5. e Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer , Imperial College London, Chelsea and Westminster Hospital , London , UK.
Abstract
Purpose/aim: We investigated the regularity changes of the retinal nerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) of the amnestic mild cognitive impairment (aMCI) patients in this prospective cohort study. MATERIALS AND METHODS: Twenty-four aMCI patients and 30 health controls, who are more than 60 years old, were recruited into the study. The RNFL and the mGCC average thickness were measured with Fourier-domain optical coherence tomography (FD-OCT). RESULTS: Compared with that in the controls, the intraocular pressure (IOP) was significantly lower in the aMCI patients. A significant decrease in RNFL thickness in superior temporal, temporal upper (TU), and temporal upper and lower (TL) (TU+TL) quadrants was found in the aMCI patients than in the controls. The average thickness of the mGCC was also significantly thinner in the aMCI patients than in the controls. CONCLUSIONS: Retinal degeneration in the aMCI patients detected by OCT together with lower IOP may indicate disease pathological progression.
Purpose/aim: We investigated the regularity changes of the retinal nerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) of the amnestic mild cognitive impairment (aMCI) patients in this prospective cohort study. MATERIALS AND METHODS: Twenty-four aMCIpatients and 30 health controls, who are more than 60 years old, were recruited into the study. The RNFL and the mGCC average thickness were measured with Fourier-domain optical coherence tomography (FD-OCT). RESULTS: Compared with that in the controls, the intraocular pressure (IOP) was significantly lower in the aMCIpatients. A significant decrease in RNFL thickness in superior temporal, temporal upper (TU), and temporal upper and lower (TL) (TU+TL) quadrants was found in the aMCIpatients than in the controls. The average thickness of the mGCC was also significantly thinner in the aMCIpatients than in the controls. CONCLUSIONS:Retinal degeneration in the aMCIpatients detected by OCT together with lower IOP may indicate disease pathological progression.
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