Randi Fuglsang Fonager1,2, Helle Damgaard Zacho1,2, Niels Christian Langkilde3, Joan Fledelius4, June Anita Ejlersen4, Helle Westergreen Hendel5, Christian Haarmark5, Mette Moe6, Jesper Carl Mortensen4, Mads Ryø Jochumsen7, Lars Jelstrup Petersen1,2. 1. a Department of Nuclear Medicine , Clinical Cancer Research Center, Aalborg University Hospital , Aalborg , Denmark. 2. b Department of Clinical Medicine , Aalborg University , Aalborg , Denmark. 3. c Department of Urology , Aalborg University Hospital , Aalborg , Denmark. 4. d Department of Nuclear Medicine , Regional Hospital West Jutland , Herning , Denmark. 5. e Department of Clinical Physiology and Nuclear Medicine , Herlev Hospital , Herlev , Denmark. 6. f Department of Oncology , Aalborg University Hospital , Aalborg , Denmark. 7. g Department of Urology , Regional Hospital West Jutland , Holstebro , Denmark.
Abstract
AIM: To compare 18F-sodium fluoride positron emission tomography/computed tomography (NaF PET/CT) and 99mTc-labelled diphosphonate bone scan (BS) for the monitoring of bone metastases in patients with prostate cancer undergoing anti-cancer treatment. MATERIAL AND METHODS: Data from 64 patients with prostate cancer were included. The patients received androgen-deprivation therapy (ADT), next-generation hormonal therapy (NGH) or chemotherapy. The patients had a baseline scan and 1-3 subsequent scans during six months of treatment. Images were evaluated by experienced nuclear medicine physicians and classified for progressive disease (PD) or non-PD according to the Prostate Cancer Working Group 2 (PCWG-2) criteria. The patients were also classified as having PD/non-PD according to the clinical and prostate-specific antigen (PSA) responses. RESULTS: There was no difference between NaF PET/CT and BS in the detection of PD and non-PD during treatment (McNemar's test, p = .18). The agreement between BS and NaF PET/CT for PD/non-PD was moderate (Cohen's kappa 0.53, 95% confidence interval 0.26-0.79). Crude agreement between BS and NaF PET/CT for the assessment of PD/non-PD was 86% (89% for ADT, n = 28; 88% for NGH, n = 16, and 80% for chemotherapy, n = 20). In most discordant cases, BS found PD when NaF PET/CT did not, or BS detected PD on an earlier scan than NaF PET/CT. Biochemical progression (27%) occurred more frequently than progression on functional imaging (BS, 22% and NaF PET/CT, 14%). Clinical progression was rare (11%), and almost exclusively seen in patients receiving chemotherapy. CONCLUSION: There was no difference between NaF PET/CT and BS in the detection of PD and non-PD; however, BS seemingly detects PD by the PCWG-2 criteria earlier than NaF-PET, which might be explained by the fact that NaF-PET is more sensitive at the baseline scan.
AIM: To compare 18F-sodium fluoride positron emission tomography/computed tomography (NaF PET/CT) and 99mTc-labelled diphosphonate bone scan (BS) for the monitoring of bone metastases in patients with prostate cancer undergoing anti-cancer treatment. MATERIAL AND METHODS: Data from 64 patients with prostate cancer were included. The patients received androgen-deprivation therapy (ADT), next-generation hormonal therapy (NGH) or chemotherapy. The patients had a baseline scan and 1-3 subsequent scans during six months of treatment. Images were evaluated by experienced nuclear medicine physicians and classified for progressive disease (PD) or non-PD according to the Prostate Cancer Working Group 2 (PCWG-2) criteria. The patients were also classified as having PD/non-PD according to the clinical and prostate-specific antigen (PSA) responses. RESULTS: There was no difference between NaF PET/CT and BS in the detection of PD and non-PD during treatment (McNemar's test, p = .18). The agreement between BS and NaF PET/CT for PD/non-PD was moderate (Cohen's kappa 0.53, 95% confidence interval 0.26-0.79). Crude agreement between BS and NaF PET/CT for the assessment of PD/non-PD was 86% (89% for ADT, n = 28; 88% for NGH, n = 16, and 80% for chemotherapy, n = 20). In most discordant cases, BS found PD when NaF PET/CT did not, or BS detected PD on an earlier scan than NaF PET/CT. Biochemical progression (27%) occurred more frequently than progression on functional imaging (BS, 22% and NaF PET/CT, 14%). Clinical progression was rare (11%), and almost exclusively seen in patients receiving chemotherapy. CONCLUSION: There was no difference between NaF PET/CT and BS in the detection of PD and non-PD; however, BS seemingly detects PD by the PCWG-2 criteria earlier than NaF-PET, which might be explained by the fact that NaF-PET is more sensitive at the baseline scan.
Authors: Helle D Zacho; Julie B Nielsen; Ali Afshar-Oromieh; Uwe Haberkorn; Nandita deSouza; Katja De Paepe; Katja Dettmann; Niels C Langkilde; Christian Haarmark; Rune V Fisker; Dennis T Arp; Jesper Carl; Jørgen B Jensen; Lars J Petersen Journal: Eur J Nucl Med Mol Imaging Date: 2018-06-06 Impact factor: 9.236
Authors: Helle D Zacho; Randi F Fonager; Julie B Nielsen; Christian Haarmark; Helle W Hendel; Martin B Johansen; Jesper C Mortensen; Lars J Petersen Journal: J Nucl Med Date: 2019-09-03 Impact factor: 11.082
Authors: Jochen Hammes; Melanie Hohberg; Philipp Täger; Markus Wild; Boris Zlatopolskiy; Philipp Krapf; Bernd Neumaier; Klaus Schomäcker; Carsten Kobe; Matthias Schmidt; Markus Dietlein; Alexander Drzezga Journal: PLoS One Date: 2018-12-20 Impact factor: 3.240