Literature DB >> 29443494

Macrophage-Instructed Intracellular Staphylococcus aureus Killing by Targeting Photodynamic Dimers.

Qian Cai1, Yue Fei2, Hong-Wei An2, Xiao-Xiao Zhao2, Yang Ma2, Yong Cong2, Liming Hu1, Li-Li Li2, Hao Wang2.   

Abstract

The survival of Staphylococcus aureus inside phagocytes is considered to be the sticking point of long-term chronic inflammation. Here, we fabricate peptide-chlorophyll-based photodynamic therapy (PDT) agents with "sandwich" dimeric structure to enhance the PDT effect and active targeting property to eliminate intracellular infections, which could be seen as prospective antibacterial agents for inflammation.

Entities:  

Keywords:  antibacterial agent; chlorophyll; infection; peptide; photodynamic therapy

Mesh：

Substances：

Year:  2018        PMID： 29443494     DOI： 10.1021/acsami.7b19056

Source DB:  PubMed          Journal:  ACS Appl Mater Interfaces        ISSN： 1944-8244            Impact factor:   9.229


  5 in total

1.  Responsive Assembly of Silver Nanoclusters with a Biofilm Locally Amplified Bactericidal Effect to Enhance Treatments against Multi-Drug-Resistant Bacterial Infections.

Authors:  Jiahe Wu; Fangyuan Li; Xi Hu; Jingxiong Lu; Xiaolian Sun; Jianqing Gao; Daishun Ling
Journal:  ACS Cent Sci       Date:  2019-06-18       Impact factor: 14.553

2.  pH responsive superporogen combined with PDT based on poly Ce6 ionic liquid grafted on SiO2 for combating MRSA biofilm infection.

Authors:  Chaoli Wang; Peng Chen; Youbei Qiao; Yuan Kang; Chaoren Yan; Zhe Yu; Jian Wang; Xin He; Hong Wu
Journal:  Theranostics       Date:  2020-03-26       Impact factor: 11.556

Review 3.  The Role of Macrophages in Staphylococcus aureus Infection.

Authors:  Grace R Pidwill; Josie F Gibson; Joby Cole; Stephen A Renshaw; Simon J Foster
Journal:  Front Immunol       Date:  2021-01-19       Impact factor: 7.561

4.  Targeted Antimicrobial Photodynamic Therapy of Biofilm-Embedded and Intracellular Staphylococci with a Phage Endolysin's Cell Binding Domain.

Authors:  Mafalda Bispo; Sílvio B Santos; Luís D R Melo; Joana Azeredo; Jan Maarten van Dijl
Journal:  Microbiol Spectr       Date:  2022-02-23

Review 5.  Emerging nanozyme-based multimodal synergistic therapies in combating bacterial infections.

Authors:  Yanmei Zhang; Xin Hu; Jing Shang; Wenhui Shao; Liming Jin; Chunshan Quan; Jun Li
Journal:  Theranostics       Date:  2022-08-08       Impact factor: 11.600
  5 in total

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