Antisense lncRNA As-SLC7A11 suppresses epithelial ovarian cancer progression mainly by targeting SLC7A11.

Antisense lncRNAs play a key role in the progression of multiple cancers. Thus, it is important to elucidate the function and mechanism of antisense lncRNAs, which may play a role in the treatment of epithelial ovarian cancer (EOC). In the current study, for the first time, we showed that the level of As-SLC7A11 was markedly reduced in EOC cancer tissues and cell lines compared with those of normal control. Further study showed that silencing of As-SLC7A11 could enhance ovarian cancer cell migration. In comparison, overexpression of As-SLC7A11 markedly induced ovarian cancer cell apoptosis. These data demonstrate the tumor suppressor role of As-SLC7A11 in ovarian cancer malignancies. We also demonstrated that overexpression of As-SLC7A11 could significantly suppress the expression of SLC7A11, indicating a negative correlation between As-SLC7A11 and SLC7A11 in ovarian cancer cells. In summary, we first showed that reduction of As-SLC7A11 level prompted ovarian cancer cell migration mainly by suppressing the expression of SLC7A11.