Long non-coding RNA SNHG1 promotes cell proliferation and tumorigenesis in colorectal cancer via Wnt/β-catenin signaling.

Nucleolar RNA Host Gene 1 (SNHG1) is responsible for initiation, progression, and metastasis of various cancers. However, the role and molecular mechanism of SNHG1 is poorly understood in colorectal cancer. Here we discovered that SNHG1 is high-expressed in colorectal cancer cells. We find that SNHG1 knockdown inhibits cell proliferation and induces apoptosis in colorectal cancer. Moreover, SNHG1 can promote the expression of target genes, and SNHG1 expression is positively correlated with WNT expression. Thus, SNHG1 regulates colorectal cancer by Wnt/β-catenin signaling pathway. Our study provides strong evidence that SNHG1 may significantly be associated with the development and progression of colorectal cancer.