| Literature DB >> 29441440 |
Xuefu Wang1, Zhigang Tian2,3.
Abstract
γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.Entities:
Keywords: autoimmune hepatitis; liver cancer; liver fibrosis and cirrhosis; liver infection; liver regeneration; non-alcoholic fatty liver disease; γδT cells
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Year: 2018 PMID： 29441440 DOI： 10.1007/s11684-017-0584-x
Source DB: PubMed Journal: Front Med ISSN： 2095-0217 Impact factor: 4.592