| Literature DB >> 29440587 |
Samuel Y Ash1, Rola Harmouche2, Rachel K Putman1, James C Ross2, Fernando J Martinez3, Augustine M Choi3, Russell P Bowler4, Elizabeth A Regan5, Jeffrey L Curtis6,7, MeiLan K Han6, Richard C Boucher8, Wanda K O'Neal8, Hiroto Hatabu9, David A Lynch10, Ivan O Rosas1, Gary M Hunninghake1, Raul San Jose Estepar2, George R Washko1.
Abstract
A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.Entities:
Keywords: copd exacerbations; idiopathic pulmonary fibrosis; interstitial fibrosis
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Year: 2018 PMID： 29440587 PMCID： PMC6089672 DOI： 10.1136/thoraxjnl-2017-211208
Source DB: PubMed Journal: Thorax ISSN： 0040-6376 Impact factor: 9.139