Targeting HSF1: A Prime Integrator of Proteotoxic Stress Response in Myeloma.

The HSF1 transcription factor is an integrator of the cellular stress response, and its expression has demonstrated poor prognosis in multiple myeloma. The novel anti-HSF1 small-molecule inhibitors CCT251236 and KRIB11 demonstrate in vitro and in vivo antimyeloma activity, representing a novel approach for targeting the heat shock response in myeloma. Clin Cancer Res; 24(10); 2237-8. ©2018 AACRSee related article by Fok et al., p. 2395. ©2018 American Association for Cancer Research.