Literature DB >> 29439974

A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens.

Yu-Wei Lin1, Ke Chen1, Jiping Wang1, Tony Velkov2, Qi Tony Zhou3, Jian Li4.   

Abstract

The efficacy of subcutaneously administered polymyxins against burn wound infections caused by Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B (30 mg/kg thrice daily) achieved a ≥2-log10 reduction in the bacterial load for P. aeruginosa and A. baumannii infections, whereas wound infections by K. pneumoniae were less responsive (<1-log10 reduction). This study highlights the potential therapeutic benefits of parenteral polymyxins for treating burn wound infections.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Acinetobacter baumannii; Klebsiella pneumoniae; Pseudomonas aeruginosa; multidrug resistance; polymyxins; thermal injury

Mesh：

Substances：

Year:  2018        PMID： 29439974      PMCID： PMC5923121          DOI： 10.1128/AAC.02527-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

1.  Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens.

Authors:  Ana M Sandri; Cornelia B Landersdorfer; Jovan Jacob; Márcio M Boniatti; Micheline G Dalarosa; Diego R Falci; Tainá F Behle; Rosaura C Bordinhão; Jiping Wang; Alan Forrest; Roger L Nation; Jian Li; Alexandre P Zavascki
Journal:  Clin Infect Dis       Date:  2013-05-22       Impact factor: 9.079

Review 2.  Physiological parameters in laboratory animals and humans.

Authors:  B Davies; T Morris
Journal:  Pharm Res       Date:  1993-07       Impact factor: 4.200

Review 3.  Infection control in the burn unit.

Authors:  Karim Rafla; Edward E Tredget
Journal:  Burns       Date:  2010-06-18       Impact factor: 2.744

4.  Aerosolized Polymyxin B for Treatment of Respiratory Tract Infections: Determination of Pharmacokinetic-Pharmacodynamic Indices for Aerosolized Polymyxin B against Pseudomonas aeruginosa in a Mouse Lung Infection Model.

Authors:  Yu-Wei Lin; Qi Zhou; Nikolas J Onufrak; Veronika Wirth; Ke Chen; Jiping Wang; Alan Forrest; Hak-Kim Chan; Jian Li
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191

5.  Pharmacokinetics/Pharmacodynamics of Pulmonary Delivery of Colistin against Pseudomonas aeruginosa in a Mouse Lung Infection Model.

Authors:  Yu-Wei Lin; Qi Tony Zhou; Soon-Ee Cheah; Jinxin Zhao; Ke Chen; Jiping Wang; Hak-Kim Chan; Jian Li
Journal:  Antimicrob Agents Chemother       Date:  2017-02-23       Impact factor: 5.191

6.  Control of endotoxemia in burn patients by use of polymyxin B.

Authors:  A M Munster; G X Xiao; Y Guo; L A Wong; R A Winchurch
Journal:  J Burn Care Rehabil       Date:  1989 Jul-Aug

Review 7.  Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients.

Authors:  Benoit Blanchet; Vincent Jullien; Christophe Vinsonneau; Michel Tod
Journal:  Clin Pharmacokinet       Date:  2008       Impact factor: 6.447

8.  Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by gram-negative bacteria.

Authors:  D Plachouras; M Karvanen; L E Friberg; E Papadomichelakis; A Antoniadou; I Tsangaris; I Karaiskos; G Poulakou; F Kontopidou; A Armaganidis; O Cars; H Giamarellou
Journal:  Antimicrob Agents Chemother       Date:  2009-05-11       Impact factor: 5.191

9.  Use of colistin in a pediatric burn unit in Argentina.

Authors:  Maria Rosanova; Carolina Epelbaum; Alejandro Noman; Mabel Villasboas; Veronica Alvarez; Griselda Berberian; Norma Sberna; Gabriela Mudryck; Roberto Lede
Journal:  J Burn Care Res       Date:  2009 Jul-Aug       Impact factor: 1.845

10.  Pseudomonas infections in the thermally injured patient.

Authors:  Edward E Tredget; Heather A Shankowsky; Robert Rennie; Robert E Burrell; Sarvesh Logsetty
Journal:  Burns       Date:  2004-02       Impact factor: 2.744
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  1 in total

1.  Interactions of two enantiomers of a designer antimicrobial peptide with structural components of the bacterial cell envelope.

Authors:  Zhou Ye; Conrado Aparicio
Journal:  J Pept Sci       Date:  2021-01-25       Impact factor: 1.905
  1 in total

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