Fanni Haapalinna1, Merja Kokki2, Olli Jääskeläinen1, Merja Hallikainen1, Seppo Helisalmi1, Anne Koivisto1,3, Hannu Kokki4, Teemu Paajanen5, Janne Penttinen1, Maria Pikkarainen1, Minna Rautiainen3, Hilkka Soininen1,3, Eino Solje1, Anne M Remes1,3,6,7, Sanna-Kaisa Herukka1. 1. Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland. 2. Department of Anesthesia and Operative Services, Kuopio University Hospital, Kuopio, Finland. 3. Department of Neurology, Kuopio University Hospital, Kuopio, Finland. 4. Institute of Clinical Medicine, Anesthesiology and Intensive Care, University of Eastern Finland, Kuopio, Finland. 5. Research and Service Centre for Occupational Health, Finnish Institute of Occupational Health, Helsinki, Finland. 6. Medical Research Center, Oulu University Hospital, Oulu, Finland. 7. Research Unit of Clinical Neuroscience, Neurology, University of Oulu, Oulu, Finland.
Abstract
BACKGROUND: The neuropathology of Alzheimer's disease (AD) has previously been shown to be rather common among the elderly. OBJECTIVE: The aim of this study was to inspect the associations between cerebrospinal fluid (CSF) AD biomarker concentrations, age, the APOEɛ4 allele, cardiovascular diseases, diabetes, and cognitive performance in a cohort of a neurologically healthy population. METHODS: This study included 93 subjects (42 men, mean age 67 years) without previous neurological symptoms or subjective cognitive complaints. Their cognition was assessed, and CSF biomarkers and APOEɛ4 status were analyzed. RESULTS: Of the studied subjects, 8.6% (n = 8) had a pathological CSF AD biomarker profile. An increase in age correlated positively with CSF tau pathology and negatively with global cognitive performance. CONCLUSION: AD-type pathological changes in CSF and subtle cognitive impairment are common within a population with no previous memory complaints. Age was the main risk factor for the changes.
BACKGROUND: The neuropathology of Alzheimer's disease (AD) has previously been shown to be rather common among the elderly. OBJECTIVE: The aim of this study was to inspect the associations between cerebrospinal fluid (CSF) AD biomarker concentrations, age, the APOEɛ4 allele, cardiovascular diseases, diabetes, and cognitive performance in a cohort of a neurologically healthy population. METHODS: This study included 93 subjects (42 men, mean age 67 years) without previous neurological symptoms or subjective cognitive complaints. Their cognition was assessed, and CSF biomarkers and APOEɛ4 status were analyzed. RESULTS: Of the studied subjects, 8.6% (n = 8) had a pathological CSF AD biomarker profile. An increase in age correlated positively with CSF tau pathology and negatively with global cognitive performance. CONCLUSION:AD-type pathological changes in CSF and subtle cognitive impairment are common within a population with no previous memory complaints. Age was the main risk factor for the changes.
Authors: Anna Jeppsson; Carsten Wikkelsö; Kaj Blennow; Henrik Zetterberg; Radu Constantinescu; Anne M Remes; Sanna-Kaisa Herukka; Tuomas Rauramaa; Katarina Nagga; Ville Leinonen; Mats Tullberg Journal: J Neurol Neurosurg Psychiatry Date: 2019-06-05 Impact factor: 10.154