Literature DB >> 2943923

Gastric lesion-preventing or -potentiating activity of clonidine in rats.

P Del Soldato.   

Abstract

The dual effects of clonidine on gastric experimental damage have been studied in the rat. At lower doses, clonidine prevents gastric lesions induced by oxotremorine plus neostigmine, probably through an alpha 2-agonist mechanism; at higher doses, the compound potentiates dimaprit-induced gastric damage, probably through an H2-agonist mechanism.

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Year:  1986        PMID： 2943923     DOI： 10.1254/jjp.41.257

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN： 0021-5198


  6 in total

1.  The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats.

Authors:  Murat Yigiter; Abdullah Yildiz; Beyzagul Polat; Hamit Hakan Alp; Osman Nuri Keles; Ahmet Bedii Salman; Halis Suleyman
Journal:  Surg Today       Date:  2011-12-28       Impact factor: 2.549

2.  Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats.

Authors:  Halis Suleyman; Zekai Halici; Elif Cadirci; Ahmet Hacimuftuoglu; Sait Keles; Fatma Gocer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-03-20       Impact factor: 3.000

Review 3.  The Role of Alpha-2 Adrenergic Receptors in Anti-ulcer Activity.

Authors:  Halis Suleyman
Journal:  Eurasian J Med       Date:  2012-04

Review 4.  Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers.

Authors:  Halis Suleyman; Abdulmecit Albayrak; Mehmet Bilici; Elif Cadirci; Zekai Halici
Journal:  Inflammation       Date:  2010-08       Impact factor: 4.092

5.  Protective effect of mirtazapine on indomethacin-induced ulcer in rats and its relationship with oxidant and antioxidant parameters.

Authors:  Mehmet Bilici; Cengiz Ozturk; Hakan Dursun; Fatih Albayrak; Mustafa Bahadir Saglam; Abdullah Uyanik; Mine Gulaboglu; Salim Basol Tekin
Journal:  Dig Dis Sci       Date:  2008-11-26       Impact factor: 3.199

6.  Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats.

Authors:  G B Glavin; D D Smyth
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739
  6 in total

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